Langerhans Cells
Definition
Langerhans Cells: Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
Annotations
cutaneous cells: do not confuse with ISLETS OF LANGERHANS (pancreas) nor with GIANT CELLS, LANGHANS (macrophages)
Other Entries
Dendritic Cells, Dermal
Dendritic Cells, Epidermal
Dendritic Cells, Skin
Dermal Dendritic Cells
Epidermal Dendritic Cells
Skin Dendritic Cells
Cell, Dermal Dendritic
Cell, Epidermal Dendritic
Cell, Skin Dendritic
Cells, Dermal Dendritic
Cells, Epidermal Dendritic
Cells, Langerhans
Cells, Skin Dendritic
Dendritic Cell, Dermal
Dendritic Cell, Epidermal
Dendritic Cell, Skin
Dermal Dendritic Cell
Epidermal Dendritic Cell
Skin Dendritic Cell
Previous Index
Cytoplasmic Granules (1966-1968)
Epithelium (1966-1968)
Skin (1966-1968)
Allowable Qualifiers
chemistry classification cytology drug effects enzymology immunology metabolism microbiology parasitology pathology physiology radiation effects radiography radionuclide imaging secretion transplantation ultrasonography ultrastructure virology
Categories
Entry Date
01-01-1999
Common Chronic Illnesses
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Diabetes Supplies | Diabetic Groups
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
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Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
