DNA Damage
Categorical breakdown of terms falling inder the category of DNA Damage. Sub categories will become more specific in nature to the terms listed for DNA Damage.
Sub-Categories
Terms
Chromosome Breakage - A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL...
Chromosome Breakpoints - The locations in specific DNA sequences where CHROMOSOME BREAKS have occurred....
DNA Adducts - The products of chemical reactions that result in the addition of extraneous chemical groups to DNA....
DNA Breaks - Interruptions in the sugar-phosphate backbone of DNA....
DNA Breaks, Double-Stranded - Interruptions in the sugar-phosphate backbone of DNA, across both strands adjacently....
DNA Breaks, Single-Stranded - Interruptions in one of the strands of the sugar-phosphate backbone of double-stranded DNA....
DNA Damage - Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left u...
DNA Degradation, Necrotic - The random catabolism of DNA accompaning the irreversible damage to tissue which leads to the pathol...
DNA Fragmentation - Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes...
Common Chronic Illnesses
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
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Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
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Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
