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Enzymes

Categorical breakdown of terms falling inder the category of Enzymes. Sub categories will become more specific in nature to the terms listed for Enzymes.

Sub-Categories

Terms

1,4-alpha-Glucan Branching Enzyme - In glycogen or amylopectin synthesis, the enzyme that catalyzes the transfer of a segment of a 1,4-a...

11-beta-Hydroxysteroid Dehydrogenase Type 1 - A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in L...

11-beta-Hydroxysteroid Dehydrogenase Type 2 - An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to c...

11-beta-Hydroxysteroid Dehydrogenases - Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive m...

15-Oxoprostaglandin 13-Reductase - (5Z)-(15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta(13)-oxidoreductase. An enzyme active...

17-Hydroxysteroid Dehydrogenases - A class of enzymes that catalyzes the oxidation of 17-hydroxysteroids to 17-ketosteroids. EC 1.1.-....

1-Acylglycerol-3-Phosphate O-Acyltransferase - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to ge...

1-Acylglycerophosphocholine O-Acyltransferase - An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transf...

1-Alkyl-2-acetylglycerophosphocholine Esterase - A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR b...

1-Phosphatidylinositol 3-Kinase - An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate....

1-Phosphatidylinositol 4-Kinase - An enzyme that catalyzes the conversion of phosphatidylinositol (PHOSPHATIDYLINOSITOLS) to phosphati...

1-Pyrroline-5-Carboxylate Dehydrogenase - An enzyme that catalyzes the oxidation of 1-pyrroline-5-carboxylate to L-GLUTAMATE in the presence o...

2',3'-Cyclic-Nucleotide Phosphodiesterases - Nucleoside-2',3'-cyclic phosphate nucleotidohydrolase. Enzymes that catalyze the hydrolysis of the 2...

2',5'-Oligoadenylate Synthetase - An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and p...

20-alpha-Hydroxysteroid Dehydrogenase - An enzymes that catalyzes the reversible reduction-oxidation reaction of 20-alpha-hydroxysteroids, s...

20-Hydroxysteroid Dehydrogenases - A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, ...

25-Hydroxyvitamin D3 1-alpha-Hydroxylase - A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin...

2-Acetolactate Mutase - An enzyme involved in the biosynthesis of isoleucine and valine. It converts 2-acetolactate into 3-h...

2-Aminoadipate Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-2-aminoadipa...

2-Isopropylmalate Synthase - An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl ma...

2-Oxoisovalerate Dehydrogenase (Acylating) - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-C...

3',5'-Cyclic-AMP Phosphodiesterases - Enzymes that catalyze the hydrolysis of CYCLIC AMP to form adenosine 5'-phosphate. The enzymes are w...

3',5'-Cyclic-GMP Phosphodiesterases - Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate....

3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DI...

3-Deoxy-7-Phosphoheptulonate Synthase - An enzyme that catalyzes the formation of 7-phospho-2-keto-3-deoxy-D-arabinoheptonate from phosphoen...

3-Hydroxyacyl CoA Dehydrogenases - Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the prese...

3-Hydroxyanthranilate 3,4-Dioxygenase - An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semial...

3-Hydroxysteroid Dehydrogenases - Catalyze the oxidation of 3-hydroxysteroids to 3-ketosteroids....

3-Isopropylmalate Dehydrogenase - An NAD+ dependent enzyme that catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate to 3...

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - A ketone oxidoreductase that catalyzes the overall conversion of alpha-keto acids to ACYL-CoA and CO...

3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - An enzyme of long-chain fatty acid synthesis, that adds a two-carbon unit from malonyl-(acyl carrier...

3-Phosphoshikimate 1-Carboxyvinyltransferase - An enzyme of the shikimate pathway of AROMATIC AMINO ACID biosynthesis, it generates 5-enolpyruvylsh...

4-Aminobutyrate Transaminase - An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semia...

4-Hydroxybenzoate-3-Monooxygenase - A flavoprotein that catalyzes the synthesis of protocatechuic acid from 4-hydroxybenzoate in the pre...

4-Hydroxyphenylpyruvate Dioxygenase - An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid ...

4-Nitrophenylphosphatase - An enzyme that catalyzes the hydrolysis of nitrophenyl phosphates to nitrophenols. At acid pH it is ...

5,10-Methylenetetrahydrofolate Reductase (FADH2) - An FAD-dependent oxidoreductase found primarily in BACTERIA. It is specific for the reduction of 5,1...

5-Aminolevulinate Synthetase - An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl c...

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetr...

5'-Nucleotidase - A glycoprotein enzyme present in various organs and in many cells. The enzyme catalyzes the hydrolys...

6-Phytase - An enzyme that catalyzes the conversion of myo-inositol hexakisphosphate and water to 1L-myo-inosito...

7-Alkoxycoumarin O-Dealkylase - A drug-metabolizing enzyme found in the hepatic, placental and intestinal microsomes that metabolize...

Abrin - A toxic lectin from the seeds of jequirity, Abrus precatorius L. Very active poison. Five different ...

Acetate Kinase - An enzyme that catalyzes reversibly the phosphorylation of acetate in the presence of a divalent cat...

Acetate-CoA Ligase - An enzyme that catalyzes the formation of CoA derivatives from ATP, acetate, and CoA to form AMP, py...

Acetoin Dehydrogenase - An enzyme that catalyzes the conversion of acetoin to diacetyl in the presence of NAD. EC 1.1.1.5....

Acetolactate Synthase - A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the b...

Acetylcholinesterase - An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this en...

Acetyl-CoA C-Acetyltransferase - An enzyme that catalyzes the formation of acetoacetyl-CoA from two molecules of ACETYL COA. Some enz...

Acetyl-CoA C-Acyltransferase - Enzyme that catalyzes the final step of fatty acid oxidation in which ACETYL COA is released and the...

Acetyl-CoA Carboxylase - A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophos...

Acetyl-CoA Hydrolase - An enzyme that catalyzes reversibly the hydrolysis of acetyl-CoA to yield CoA and acetate. The enzym...

Acetylesterase - An enzyme that catalyzes the conversion of acetate esters and water to alcohols and acetate. EC 3.1....

Acetylglucosaminidase - A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-...

Acetylserotonin O-Methyltransferase - An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylseroton...

Acetyltransferases - Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compo...

Acid Anhydride Hydrolases - A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside...

Acid Ceramidase - A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradati...

Acid Phosphatase - An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and ...

Aconitate Hydratase - An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. I...

Acrosin - A trypsin-like enzyme of spermatozoa which is not inhibited by alpha 1 antitrypsin....

Activin Receptors - Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREON...

Activin Receptors, Type I - One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are severa...

Activin Receptors, Type II - One of the two types of ACTIVIN RECEPTORS. They are membrane protein kinases belonging to the family...

Acyl-Carrier Protein S-Acetyltransferase - A enzyme that catalyzes the transfer of acetyl groups from ACETYL CoA to acyl-carrier protein to for...

Acyl-Carrier Protein S-Malonyltransferase - This enzyme catalyzes the transacylation of malonate from MALONYL CoA to activated holo-ACP, to gene...

Acyl-CoA Dehydrogenase - A flavoprotein oxidoreductase that has specificity for medium-chain fatty acids. It forms a complex ...

Acyl-CoA Dehydrogenase, Long-Chain - A flavoprotein oxidoreductase that has specificity for long-chain fatty acids. It forms a complex wi...

Acyl-CoA Dehydrogenases - Enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS....

Acyl-CoA Oxidase - An enzyme that catalyzes the first and rate-determining steps of peroxisomal beta-oxidation of fatty...

Acyltransferases - Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor,...

ADAM Proteins - A family of membrane-anchored glycoproteins that contain a disintegrin and metalloprotease domain. T...

Adenine Phosphoribosyltransferase - An enzyme catalyzing the formation of AMP from adenine and phosphoribosylpyrophosphate. It can act a...

Adenosine Deaminase - An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Sin...

Adenosine Kinase - An enzyme that catalyzes the formation of ADP plus AMP from adenosine plus ATP. It can serve as a sa...

Adenosine Triphosphatases - A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled ...

Adenosylhomocysteinase - An enzyme which catalyzes the catabolism of S-ADENOSYLHOMOCYSTEINE to ADENOSINE and HOMOCYSTEINE. It...

Adenosylmethionine Decarboxylase - An enzyme that catalyzes the decarboxylation of S-adenosyl-L-methionine to yield 5'-deoxy-(5'-),3-am...

Adenylate Cyclase - An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. ...

Adenylate Cyclase Toxin - One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein...

Adenylate Kinase - An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triph...

Adenylosuccinate Lyase - An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-...

Adenylosuccinate Synthase - A carbon-nitrogen ligase. During purine ribonucleotide biosynthesis, this enzyme catalyzes the synth...

ADP Ribose Transferases - Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Tran...

ADP-ribosyl Cyclase - A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from ...

ADP-Ribosylation Factor 1 - ADP-RIBOSYLATION FACTOR 1 is involved in regulating intracellular transport by modulating the intera...

ADP-Ribosylation Factors - MONOMERIC GTP-BINDING PROTEINS that were initially recognized as allosteric activators of the MONO(A...

Alanine Dehydrogenase - An NAD-dependent enzyme that catalyzes the reversible DEAMINATION of L-ALANINE to PYRUVATE and AMMON...

Alanine Racemase - A pyridoxal-phosphate protein that reversibly catalyzes the conversion of L-alanine to D-alanine. EC...

Alanine Transaminase - An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate....

Alanine-tRNA Ligase - An enzyme that activates alanine with its specific transfer RNA. EC 6.1.1.7....

Alcohol Dehydrogenase - A zinc-containing enzyme which oxidizes primary and secondary alcohols or hemiacetals in the presenc...

Alcohol Oxidoreductases - A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as ...

Aldehyde Dehydrogenase - An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzy...

Aldehyde Oxidase - An aldehyde oxidoreductase expressed predominantly in the LIVER; LUNGS; and KIDNEY. It catalyzes the...

Aldehyde Oxidoreductases - Oxidoreductases that are specific for ALDEHYDES....

Aldehyde Reductase - An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad spe...

Aldehyde-Ketone Transferases - Enzymes that catalyze the transfer of aldehyde or ketone residues. EC 2.2....

Aldehyde-Lyases - Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a car...

Aldose-Ketose Isomerases - Enzymes that catalyze the interconversion of aldoses and ketoses. EC 5.3.1....

Aldosterone Synthase - A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presen...

Alkaline Ceramidase - A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTE...

Alkaline Phosphatase - An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and ...

Alkane 1-Monooxygenase - A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons...

Alkyl and Aryl Transferases - A somewhat heterogeneous class of enzymes that catalyze the transfer of alkyl or related groups (exc...

Allophanate Hydrolase - An enzyme that catalyzes the hydrolysis of allophanic acid to two molecules of ammonia plus two mole...

alpha-Amylases - Enzymes that catalyze the endohydrolysis of 1,4-alpha-glycosidic linkages in STARCH; GLYCOGEN; and r...

alpha-Galactosidase - An enzyme that catalyzes the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alph...

alpha-Glucosidases - Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-gluco...

alpha-L-Fucosidase - An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Def...

alpha-Mannosidase - An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-...

alpha-N-Acetylgalactosaminidase - A hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-a...

Amide Synthases - Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the ...

Amidine-Lyases - These enzymes catalyze the elimination of ammonia from amidines with the formation of a double bond....

Amidinotransferases - Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to a...

Amidophosphoribosyltransferase - An enzyme, involved in the early steps of purine nucleotide biosynthesis, that catalyzes the formati...

Amine Oxidase (Copper-Containing) - A group of enzymes including those oxidizing primary monoamines, diamines, and histamine. They are c...

Amino Acid Isomerases - Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids ...

Amino Acid Oxidoreductases - A class of enzymes that catalyze oxidation-reduction reactions of amino acids....

Amino Acyl-tRNA Synthetases - A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AM...

Amino-Acid N-Acetyltransferase - A mitochondrial matrix enzyme that catalyzes the synthesis of L-GLUTAMATE to N-acetyl-L-glutamate in...

Aminoacyltransferases - Enzymes that catalyze the transfer of an aminoacyl group from donor to acceptor resulting in the for...

Aminomethyltransferase - A one-carbon group transferase that transfers lipoamide-linked methylamine groups to tetrahydrofolat...

Aminomuconate-Semialdehyde Dehydrogenase - An NAD+ dependent enzyme that catalyzes the oxidation of 2-aminomuconate 6-semialdehyde to 2-aminomu...

Aminopeptidases - A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single...

Ammonia-Lyases - Enzymes that catalyze the formation of a carbon-carbon double bond by the elimination of AMMONIA. E...

AMP Deaminase - An enzyme that catalyzes the deamination of AMP to IMP. EC 3.5.4.6....

AMP-Activated Protein Kinases - Intracellular signaling protein kinases that play a signaling role in the regulation of cellular ene...

Amylases - A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman,...

Amyloid Precursor Protein Secretases - Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to...

Ancrod - An enzyme fraction from the venom of the Malayan pit viper, Agkistrodon rhodostoma. It catalyzes the...

Aniline Hydroxylase - A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxy...

Anistreplase - An acylated inactive complex of streptokinase and human lysine-plasminogen. After injection, the acy...

Annexin A3 - A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate a...

Anthranilate Phosphoribosyltransferase - An enzyme that catalyzes the formation of N-5'-phosphoribosylanthranilic acid from anthranilate and ...

Anthranilate Synthase - An enzyme that catalyzes the formation of anthranilate (o-aminobenzoate) and pyruvic acid from chori...

Antigens, CD13 - Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. Th...

Antigens, CD26 - Cell-surface glycoproteins and serine protease, also known as dipeptidyl-peptidase IV, that plays a ...

Antigens, CD38 - A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from ...

Antigens, CD45 - High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopo...

Apoenzymes - The protein components of enzyme complexes (HOLOENZYMES). An apoenzyme is the holoenzyme minus any c...

Apoptosis Inducing Factor - A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS w...

Apyrase - A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It ...

Arachidonate 12-Lipoxygenase - An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-H...

Arachidonate 15-Lipoxygenase - An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-H...

Arachidonate 5-Lipoxygenase - An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPE...

Arachidonate Lipoxygenases - Enzymes catalyzing the oxidation of arachidonic acid to hydroperoxyarachidonates. These products are...

Arginase - A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITH...

Arginine Kinase - An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence o...

Arginine-tRNA Ligase - An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19....

Argininosuccinate Lyase - An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence le...

Argininosuccinate Synthase - An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline an...

Aromatase - An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and convert...

Aromatic-L-Amino-Acid Decarboxylases - An enzyme group with broad specificity. The enzymes decarboxylate a range of aromatic amino acids in...

Arsenate Reductases - Oxidoreductases that specifically reduce arsenate ion to arsenite ion. Reduction of arsenate is a cr...

Arsenite Transporting ATPases - Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are prim...

Aryl Hydrocarbon Hydroxylases - A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OX...

Arylalkylamine N-Acetyltransferase - An acetyltransferase with specificity towards the amine group of aromatic alkylamines (arylalkylamin...

Arylamine N-Acetyltransferase - An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also ca...

Aryldialkylphosphatase - An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and ...

Arylformamidase - An enzyme that catalyzes the conversion of N-formyl-L-kynurenine and water to formate and L-kynureni...

Arylsulfatases - Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatas...

Arylsulfotransferase - A sulfotransferase that catalyzes the sulfation of a phenol in the presence of 3'-phosphoadenylylsul...

Ascorbate Oxidase - An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3....

Asparaginase - A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1....

Aspartate Aminotransferase, Cytoplasmic - An aspartate aminotransferase found in the CYTOPLASM....

Aspartate Aminotransferase, Mitochondrial - An aspartate aminotransferase found in MITOCHONDRIA....

Aspartate Aminotransferases - Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to ...

Aspartate Ammonia-Lyase - An enzyme that catalyzes the conversion of aspartic acid to ammonia and fumaric acid in plants and s...

Aspartate Carbamoyltransferase - An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophospha...

Aspartate Kinase - An enzyme that catalyzes the formation of beta-aspartyl phosphate from aspartic acid and ATP. Threon...

Aspartate-Ammonia Ligase - An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence...

Aspartate-Semialdehyde Dehydrogenase - An enzyme that catalyzes the conversion of L-aspartate 4-semialdehyde, orthophosphate, and NADP+ to ...

Aspartate-tRNA Ligase - An enzyme that activates aspartic acid with its specific transfer RNA. EC 6.1.1.12....

Aspartic Acid Endopeptidases - A sub-subclass of endopeptidases that depend on an ASPARTIC ACID residue for their activity....

Aspartic Acid Proteases - A subclass of peptide hydrolases that depend on an ASPARTIC ACID residue for their activity....

Aspartokinase Homoserine Dehydrogenase - An enzyme complex consisting of aspartokinase, EC 2.7.2.4, and homoserine dehydrogenase, EC 1.1.1.3....

Aspartylglucosylaminase - An enzyme that catalyzes the conversion of N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine and wate...

ATP Citrate (pro-S)-Lyase - An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield ac...

ATP Phosphoribosyltransferase - An enzyme that catalyzes the first step of the pathway for histidine biosynthesis in Salmonella typh...

ATP Synthetase Complexes - Multisubunit enzyme complexes that synthesize ADENOSINE TRIPHOSPHATE from energy sources such as ion...

ATP-Dependent Endopeptidases - Endoproteases that contain proteolytic core domains and ATPase-containing regulatory domains....

ATP-Dependent Proteases - Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. They are u...

Atrial Myosins - Myosin type II isoforms specifically found in the atrial muscle of the heart....

Autocrine Motility Factor - A protein cytokine secreted by tumor cells. It elicits increases in cell motility and phosphoinositi...

Axonemal Dyneins - Dyneins that are responsible for ciliary and flagellar beating....

Bacterial Proton-Translocating ATPases - Membrane-bound proton-translocating ATPases that serve two important physiological functions in bact...

Batroxobin - A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasm...

Benzaldehyde Dehydrogenase (NADP+) - An NADP+ dependent enzyme that catalyzes the oxidation of benzaldehyde to BENZOIC ACID. It also pla...

Benzoate 4-Monooxygenase - An enzyme that catalyzes the oxidation of BENZOATE to 4-hydroxybenzoate. It requires IRON and tetrah...

Benzopyrene Hydroxylase - A drug-metabolizing, cytochrome P-448 (P-450) enzyme which catalyzes the hydroxylation of benzopyren...

Benzylamine Oxidase - An aspect of monoamine oxidase, EC 1.4.3.4. Catalyzes the oxidation of benzylamine to form benzaldeh...

beta-Adrenergic Receptor Kinases - G-protein-coupled receptor kinases that mediate agonist-dependent PHOSPHORYLATION and desensitizatio...

beta-Alanine-Pyruvate Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of an amino group from L-ALANINE...

beta-Amylase - An enzyme that catalyzes the hydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and re...

beta-Carotene 15,15'-Monooxygenase - A monooxygenase that catalyzes the conversion of BETA-CAROTENE into two molecules of RETINAL. It was...

beta-Fructofuranosidase - A glycoside hydrolase found primarily in PLANTS and YEASTS. It has specificity for beta-D-fructofura...

beta-Galactosidase - A group of enzymes that catalyzes the hydrolysis of terminal, non-reducing beta-D-galactose residues...

beta-Glucosidase - An exocellulase with specificity for a variety of beta-D-glycoside substrates. It catalyzes the hydr...

beta-Hexosaminidase alpha Chain - The alpha subunit of hexosaminidase A. Mutations in the gene that encodes this protein can result in...

beta-Hexosaminidase beta Chain - The beta subunit of hexosaminidase A and hexosamininidase B. Mutations in the gene that encodes this...

Betaine-Aldehyde Dehydrogenase - An NAD+ dependent enzyme that catalyzes the oxidation of betain aldehyde to BETAINE....

Betaine-Homocysteine S-Methyltransferase - A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to p...

beta-Lactamases - Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ri...

beta-Mannosidase - An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-...

beta-N-Acetyl-Galactosaminidase - A hexosiminidase that specifically hydrolyzes terminal non-reducing N-acetyl-D-galactosamine residue...

beta-N-Acetylglucosaminylglycopeptide beta-1,4-Galactosyltransferase - An enzyme that catalyzes the transfer of galactose from UDP-galactose to a specific glycoprotein rec...

beta-N-Acetylhexosaminidases - A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosam...

Biotinidase - An enzyme which catalyzes the release of BIOTIN from biocytin. In human, defects in the enzyme are t...

Bisphosphoglycerate Mutase - An enzyme that catalyzes the transfer of phosphate from C-3 of 1,3-diphosphoglycerate to C-2 of 3-ph...

Bone Morphogenetic Protein 1 - A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase do...

Bone Morphogenetic Protein Receptors - A family of CELL SURFACE RECEPTORS that bind BONE MORPHOGENETIC PROTEINS. They are PROTEIN-SERINE-TH...

Bone Morphogenetic Protein Receptors, Type I - A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS...

Bone Morphogenetic Protein Receptors, Type II - A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS....

Brinolase - A fibrinolytic and thrombolytic enzyme from Aspergillus oryzae. EC 3.4.99.-....

Bromelains - Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes ...

Butyrylcholinesterase - An aspect of cholinesterase (EC 3.1.1.8)....

Butyryl-CoA Dehydrogenase - A flavoprotein oxidoreductase that has specificity for short-chain fatty acids. It forms a complex w...

Ca(2+) Mg(2+)-ATPase - An enzyme that catalyzes the hydrolysis of ATP and is activated by millimolar concentrations of eith...

Calcineurin - A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calc...

Calcium-Calmodulin-Dependent Protein Kinase Kinase - A regulatory calcium-calmodulin-dependent protein kinase that specifically phosphorylates CALCIUM-CA...

Calcium-Calmodulin-Dependent Protein Kinase Type 1 - A monomeric calcium-calmodulin-dependent protein kinase subtype that is expressed in a broad variety...

Calcium-Calmodulin-Dependent Protein Kinase Type 2 - A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric p...

Calcium-Calmodulin-Dependent Protein Kinase Type 4 - A monomeric calcium-calmodulin-dependent protein kinase subtype that is primarily expressed in neuro...

Calcium-Calmodulin-Dependent Protein Kinases - A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also so...

Calcium-Transporting ATPases - Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM....

Calpain - Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEU...

Camphor 5-Monooxygenase - A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidare...

Carbamoyl-Phosphate Synthase (Ammonia) - An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia....

Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) - An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamin...

Carbohydrate Dehydrogenases - Reversibly catalyze the oxidation of a hydroxyl group of carbohydrates to form a keto sugar, aldehyd...

Carbohydrate Epimerases - Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives....

Carbon-Carbon Double Bond Isomerases - Enzymes that catalyze the shifting of a carbon-carbon double bond from one position to another withi...

Carbon-Carbon Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These a...

Carbon-Carbon Lyases - Enzymes that catalyze the cleavage of a carbon-carbon bond by means other than hydrolysis or oxidati...

Carbonic Anhydrase I - A cytosolic carbonic anhydrase isoenzyme primarily expressed in ERYTHROCYTES, vascular endothelial c...

Carbonic Anhydrase II - A cytosolic carbonic anhydrase isoenzyme found widely distributed in cells of almost all tissues. De...

Carbonic Anhydrase III - A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL)....

Carbonic Anhydrase IV - A membrane-bound carbonic anhydrase found in lung capillaries and kidney....

Carbonic Anhydrase V - A carbonic anhydrase isoenzyme found in MITOCHONDRIA where it provides bicarbonate ions that are com...

Carbonic Anhydrases - A family of zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They p...

Carbon-Nitrogen Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6....

Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor - Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is ...

Carbon-Nitrogen Lyases - Enzymes that catalyze the cleavage of a carbon-nitrogen bond by means other than hydrolysis or oxida...

Carbon-Oxygen Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-oxygen bond. EC 6.1....

Carbon-Oxygen Lyases - Enzymes that catalyze the cleavage of a carbon-oxygen bond by means other than hydrolysis or oxidati...

Carbon-Sulfur Ligases - Enzymes that catalyze the joining of two molecules by the formation of a carbon-sulfur bond. EC 6.2....

Carbon-Sulfur Lyases - Enzymes that catalyze the cleavage of a carbon-sulfur bond by means other than hydrolysis or oxidati...

Carboxyl and Carbamoyl Transferases - A group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3....

Carboxylesterase - Carboxylesterase is a serine-dependent esterase with wide substrate specificity. The enzyme is invol...

Carboxylic Ester Hydrolases - Enzymes which catalyze the hydrolysis of carboxylic acid esters with the formation of an alcohol and...

Carboxy-Lyases - Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal o...

Carboxypeptidase B - A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. The enzyme catalyzes the pr...

Carboxypeptidase H - A ZINC-containing exopeptidase primarily found in SECRETORY VESICLES of endocrine and neuroendocrine...

Carboxypeptidase U - A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active pepti...

Carboxypeptidases - Enzymes that act at a free C-terminus of a polypeptide to liberate a single amino acid residue....

Carboxypeptidases A - Carboxypeptidases that are primarily found the DIGESTIVE SYSTEM that catalyze the release of C-termi...

Cardiac Myosins - Myosin type II isoforms found in cardiac muscle....

Carnitine Acyltransferases - Acyltransferases in the inner mitochondrial membrane that catalyze the reversible transfer of acyl g...

Carnitine O-Acetyltransferase - An enzyme that catalyzes the formation of O-acetylcarnitine from acetyl-CoA plus carnitine. EC 2.3.1...

Carnitine O-Palmitoyltransferase - An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inn...

Casein Kinase I - A casein kinase that was originally described as a monomeric enzyme with a molecular weight of 30-40...

Casein Kinase Ialpha - A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the CELL...

Casein Kinase Idelta - A casein kinase I isoenzyme that plays a regulatory role in a variety of cellular functions includin...

Casein Kinase Iepsilon - A casein kinase I isoenzyme with specificity for proteins involved the regulation of the CIRCADIAN R...

Casein Kinase II - A ubiquitous casein kinase that is comprised of two distinct catalytic subunits and dimeric regulato...

Casein Kinases - A group of protein-serine-threonine kinases that was originally identified as being responsible for ...

Caspase 1 - A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays...

Caspase 10 - A long pro-domain caspase that contains a death effector domain in its pro-domain region. Activation...

Caspase 12 - A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspa...

Caspase 14 - A short pro-domain caspase that is almost exclusively expressed in the EPIDERMIS and may play a role...

Caspase 2 - A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activ...

Caspase 3 - A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CA...

Caspase 6 - A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CA...

Caspase 7 - A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CA...

Caspase 8 - A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 ...

Caspase 9 - A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspa...

Caspases - A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and AP...

Caspases, Effector - A subclass of caspases that contain short pro-domain regions. They are activated by the proteolytic ...

Caspases, Initiator - A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzym...

Catalase - An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is pres...

Catechol 1,2-Dioxygenase - An enzyme that catalyzes the oxidation of catechol to muconic acid with the use of Fe3+ as a cofacto...

Catechol 2,3-Dioxygenase - Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE ...

Catechol O-Methyltransferase - Enzyme that catalyzes the movement of a methyl group from S-adenosylmethionone to a catechol or a ca...

Catechol Oxidase - An enzyme of the oxidoreductase class that catalyzes the reaction between catechol and oxygen to yie...

Cathepsin A - A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. I...

Cathepsin B - A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present ...

Cathepsin C - A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays...

Cathepsin D - An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower...

Cathepsin E - An aspartic endopeptidase that is similar in structure to CATHEPSIN D. It is found primarily in the ...

Cathepsin F - A lysosomal papain-related cysteine proteinase that is expressed in a broad variety of cell types....

Cathepsin G - A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity simil...

Cathepsin H - An ubiquitously-expressed lysosomal cysteine protease that is involved in protein processing. The en...

Cathepsin K - A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESO...

Cathepsin L - A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEI...

Cathepsin W - A cysteine endopeptidase found in NATURAL KILLER CELLS and CYTOTOXIC T-LYMPHOCYTES. It may have a s...

Cathepsin Z - A ubiquitously-expressed cysteine peptidase that exhibits carboxypeptidase activity. It is highly e...

Cathepsins - A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal ...

CDC2 Protein Kinase - Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL ...

cdc25 Phosphatases - A subclass of dual specificity phosphatases that play a role in the progression of the CELL CYCLE. T...

CDC28 Protein Kinase, S cerevisiae - A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression fro...

CDC2-CDC28 Kinases - A family of cell cycle-dependent kinases that are related in structure to CDC28 PROTEIN KINASE; S CE...

cdc42 GTP-Binding Protein - A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array ...

cdc42 GTP-Binding Protein, Saccharomyces cerevisiae - A member of the Rho family of MONOMERIC GTP-BINDING PROTEINS from SACCHAROMYCES CEREVISIAE. It is in...

CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase - An enzyme that catalyzes the formation of PHOSPHATIDYLINOSITOL and CMP from CDP-DIACYLGLYCEROL and M...

CDPdiacylglycerol-Serine O-Phosphatidyltransferase - An enzyme that catalyzes the formation of phosphatidylserine and CMP from CDPdiglyceride plus serine...

Cellulase - An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, l...

Cellulases - A family of glycosidases that hydrolyse crystalline CELLULOSE into soluble sugar molecules. Within t...

Cellulose 1,4-beta-Cellobiosidase - An exocellulase with specificity for the hydrolysis of 1,4-beta-D-glucosidic linkages in CELLULOSE a...

Ceramidases - Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases a...

Cerebroside-Sulfatase - An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside ...

Chaperonin 60 - A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is a...

Chaperonin Containing TCP-1 - A group II chaperonin found in eukaryotic CYTOSOL. It is comprised of eight subunits with each subun...

Chaperonins - A family of multisubunit protein complexes that form into large cylindrical structures which bind to...

Chitin Synthase - An enzyme that converts UDP glucosamine into chitin and UDP. EC 2.4.1.16....

Chloramphenicol O-Acetyltransferase - An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Sinc...

Chloride Peroxidase - An enzyme that catalyzes the chlorination of a range of organic molecules, forming stable carbon-chl...

Chloroplast Proton-Translocating ATPases - Proton-translocating ATPases which produce ADENOSINE TRIPHOSPHATE in plants. They derive energy from...

Cholera Toxin - An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit ...

Cholestenone 5 alpha-Reductase - An oxidoreductase that catalyzes the conversion of compounds that contain 5-alpha-cholestan-3-one in...

Cholesterol 7-alpha-Hydroxylase - A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in t...

Cholesterol Oxidase - An enzyme that catalyzes the oxidation of cholesterol in the presence of molecular oxygen to 4-chole...

Cholesterol Side-Chain Cleavage Enzyme - A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to ...

Choline Dehydrogenase - An enzyme bound to the inner mitochondrial membrane that catalyzes the oxidation of CHOLINE to BETAI...

Choline Kinase - An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by ca...

Choline O-Acetyltransferase - An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6....

Choline-Phosphate Cytidylyltransferase - An enzyme that catalyzes the transfer of cytidylate (CMP) to choline phosphate to form CDPcholine. I...

Chondro-4-Sulfatase - An enzyme from the sulfuric ester hydrolase class that breaks down one of the products of the chondr...

Chondroitin ABC Lyase - An enzyme that catalyzes the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosa...

Chondroitin Lyases - Enzymes which catalyze the elimination of delta-4,5-D-glucuronate residues from polysaccharides cont...

Chondroitinases and Chondroitin Lyases - Enzymes which catalyze the elimination of glucuronate residues from chondroitin A,B, and C or which ...

Chondroitinsulfatases - A group of enzymes that catalyze the hydrolysis of various sulfate bonds of chondroitin sulfate. EC ...

Chorismate Mutase - An isomerase that catalyzes the conversion of chorismic acid to prephenic acid. EC 5.4.99.5....

Chymases - A family of neutral serine proteases with CHYMOTRYPSIN-like activity. Chymases are primarily found i...

Chymopapain - A cysteine endopeptidase isolated from papaya latex. Preferential cleavage at glutamic and aspartic ...

Chymosin - The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is s...

Chymotrypsin - A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the ...

cis-trans-Isomerases - Enzymes that catalyze the rearrangement of geometry about double bonds. EC 5.2....

Citrate (si)-Synthase - Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyz...

CLOCK Proteins - Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSF...

Coagulase - Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are...

Coenzyme A Ligases - Enzymes that catalyze the formation of acyl-CoA derivatives. EC 6.2.1....

Coenzyme A-Transferases - Enzymes which transfer coenzyme A moieties from acyl- or acetyl-CoA to various carboxylic acceptors ...

Collagenases - Enzymes that catalyze the degradation of collagen by acting on the peptide bonds. EC 3.4.24.-....

Complement Activating Enzymes - Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the format...

Complement C1r - A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact comple...

Complement C1s - A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proe...

Complement Factor B - A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERN...

Complement Factor D - A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cle...

Complement Factor I - A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofac...

Coproporphyrinogen Oxidase - An enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinog...

Cortisone Reductase - An enzyme that catalyzes the interconversion of a ketone and hydroxy group at C-20 of cortisone and ...

Creatine Kinase - A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores A...

Creatine Kinase, BB Form - A form of creatine kinase found in the BRAIN....

Creatine Kinase, MB Form - An isoenzyme of creatine kinase found in the CARDIAC MUSCLE....

Creatine Kinase, Mitochondrial Form - A form of creatine kinase found in the MITOCHONDRIA....

Creatine Kinase, MM Form - An isoenzyme of creatine kinase found in the MUSCLE....

CREB-Binding Protein - A member of the p300-CBP transcription factor family that was initially identified as a binding part...

Cullin Proteins - A family of structurally related proteins that were originally discovered for their role in cell-cyc...

Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - Specific enzyme subunits that form the active sites of the type I and type II cyclic-AMP protein kin...

Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - A type I cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP ...

Cyclic AMP-Dependent Protein Kinase RIbeta Subunit - A type I cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP ...

Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit - A type II cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP...

Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit - A type II cAMP-dependent protein kinase regulatory subunit that plays a role in confering CYCLIC AMP...

Cyclic AMP-Dependent Protein Kinase Type I - A cyclic AMP-dependent protein kinase subtype primarily found in the CYTOPLASM. They are tetrameric ...

Cyclic AMP-Dependent Protein Kinase Type II - A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. ...

Cyclic AMP-Dependent Protein Kinases - A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or TH...

Cyclic GMP-Dependent Protein Kinases - A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or t...

Cyclic Nucleotide Phosphodiesterases, Type 1 - A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members ...

Cyclic Nucleotide Phosphodiesterases, Type 2 - A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an...

Cyclic Nucleotide Phosphodiesterases, Type 3 - A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an...

Cyclic Nucleotide Phosphodiesterases, Type 4 - A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells an...

Cyclic Nucleotide Phosphodiesterases, Type 5 - A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found ...

Cyclic Nucleotide Phosphodiesterases, Type 6 - A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found ...

Cyclic Nucleotide Phosphodiesterases, Type 7 - A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC AMP. Several isof...

Cyclic Nucleotide-Regulated Protein Kinases - A group of enzymes that catalyzes the phosphorylation of serine or threonine residues of proteins an...

Cyclin-Dependent Kinase 2 - A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE ...

Cyclin-Dependent Kinase 3 - A cyclin-dependent kinase that forms a complex with CYCLIN C and is active during the G1 PHASE of th...

Cyclin-Dependent Kinase 4 - Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN ...

Cyclin-Dependent Kinase 5 - A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CE...

Cyclin-Dependent Kinase 6 - Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during ...

Cyclin-Dependent Kinase 8 - A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is ac...

Cyclin-Dependent Kinase 9 - A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DI...

Cyclin-Dependent Kinases - Protein kinases that control cell cycle progression in all eukaryotes and require physical associati...

Cyclooxygenase 1 - A constitutively-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important rol...

Cyclooxygenase 2 - An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in...

Cyclophilin A - A 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cy...

Cyclophilins - A family of peptidyl-prolyl cis-trans isomerases that bind to CYCLOSPORINS and regulate the IMMUNE S...

Cystathionine beta-Synthase - A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it cataly...

Cystathionine gamma-Lyase - A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it c...

Cysteine Dioxygenase - An enzyme that catalyzes the conversion of L-CYSTEINE to 3-sulfinoalanine (3-sulfino-L-alanine) in t...

Cysteine Endopeptidases - ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is ina...

Cysteine Proteases - A subclass of peptide hydrolases that depend on a CYSTEINE residue for their activity....

Cysteine Synthase - An enzyme that catalyzes the biosynthesis of cysteine in microorganisms and plants from O-acetyl-L-s...

Cystinyl Aminopeptidase - A zinc-containing sialoglycoprotein that is used to study aminopeptidase activity in the pathogenesi...

Cytidine Deaminase - An enzyme that catalyzes the deamination of cytidine, forming uridine. EC 3.5.4.5....

Cytochrome b6f Complex - A protein complex that includes CYTOCHROME B6 and CYTOCHROME F. It is found in the THYLAKOID MEMBRAN...

Cytochrome P-450 CYP1A1 - A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as pol...

Cytochrome P-450 CYP1A2 - A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver...

Cytochrome P-450 CYP27A1 - An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol in...

Cytochrome P-450 CYP2B1 - A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTE...

Cytochrome P-450 CYP2D6 - A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals,...

Cytochrome P-450 CYP2E1 - An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solv...

Cytochrome P-450 CYP3A - A cytochrome P-450 monooxygenase that is involved in an NADPH-dependent electron transport pathway b...

Cytochrome P-450 Enzyme System - A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum...

Cytochrome-B(5) Reductase - A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due t...

Cytochrome-c Peroxidase - A hemeprotein which catalyzes the oxidation of ferrocytochrome c to ferricytochrome c in the presenc...

Cytochromes b6 - Cytochromes of the b group that are found as components of the CYTOCHROME B6F COMPLEX. They contain ...

Cytochromes f - Cytochromes f are found as components of the CYTOCHROME B6F COMPLEX. They play important role in the...

Cytoplasmic Dyneins - Dyneins that are responsible for intracellular transport, MITOSIS, cell polarization, and movement w...

Cytosine Deaminase - An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can a...

D-Alanine Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transfer of an amino group bet...

D-Aspartate Oxidase - An FAD-dependent peroxisomal flavoenzyme, this catalyzes the oxidative deamination of D-ASPARTATE to...

DCMP Deaminase - An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and...

DEAD Box Protein 20 - A multifunctional protein that is both a DEAD-box RNA helicase and a component of the SMN protein c...

DEAD-box RNA Helicases - A large family of RNA helicases that share a common protein motif with the single letter amino acid ...

Dehydroascorbatase - Catalyzes the hydrolysis of the gamma lactone, dehydroascorbate, to diketogulonate....

delta-Crystallins - A subclass of crystallins found in the lens (LENS, CRYSTALLINE) in BIRDS and REPTILES. They are inac...

Deoxycytidine Kinase - An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nuc...

Deoxyribodipyrimidine Photo-Lyase - An enzyme that catalyzes the reactivation by light of UV-irradiated DNA. It breaks two carbon-carbon...

Deoxyribonuclease (Pyrimidine Dimer) - An enzyme which catalyzes an endonucleolytic cleavage near PYRIMIDINE DIMERS to produce a 5'-phospha...

Deoxyribonuclease BamHI - One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the seq...

Deoxyribonuclease EcoRI - One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the seq...

Deoxyribonuclease HindIII - One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the seq...

Deoxyribonuclease HpaII - One of the Type II site-specific deoxyribonucleases (EC 3.1.21.4). It recognizes and cleaves the seq...

Deoxyribonuclease I - An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, prefer...

Deoxyribonuclease IV (Phage T4-Induced) - An enzyme which catalyzes the endonucleolytic cleavage of phosphodiester bonds at purinic or apyrim...

Deoxyribonucleases - Enzymes which catalyze the hydrolases of ester bonds within DNA. EC 3.1.-....

Deoxyribonucleases, Type I Site-Specific - Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magn...

Deoxyribonucleases, Type II Site-Specific - Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity...

Deoxyribonucleases, Type III Site-Specific - Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity...

Diacylglycerol Cholinephosphotransferase - An enzyme that catalyzes the synthesis of phosphatidylcholines from CDPcholine and 1,2-diacylglycero...

Diacylglycerol Kinase - An enzyme of the transferase class that uses ATP to catalyze the phosphorylation of diacylglycerol t...

Diacylglycerol O-Acyltransferase - An enzyme that catalyses the last step of the TRIACYLGLYCEROL synthesis reaction in which diacylglyc...

Dihydrodipicolinate Reductase - An enzyme that catalyzes the oxidation of 2,3,4,5-tetrahydrodipicolinate to 2,3-dihydrodipicolinate ...

Dihydrolipoamide Dehydrogenase - A flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield ...

Dihydrolipoyllysine-Residue Acetyltransferase - An enzyme that catalyzes the acetyltransferase reaction using ACETYL CoA as an acetyl donor and dihy...

Dihydroorotase - An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water...

Dihydroorotate Oxidase - An enzyme that in the course of pyrimidine biosynthesis, catalyzes the oxidation of dihydro-orotic a...

Dihydropteridine Reductase - An enzyme that catalyzes the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine in the...

Dihydropteroate Synthase - An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropterid...

Dihydrouracil Dehydrogenase (NAD+) - An enzyme that catalyzes the oxidation of 5,6-dihydrouracil to URACIL using NAD as a cofactor. This ...

Dihydrouracil Dehydrogenase (NADP) - An oxidoreductase involved in pyrimidine base degradation. It catalyzes the catabolism of THYMINE; U...

Dimethylallyltranstransferase - An enzyme that, in the pathway of cholesterol biosynthesis, catalyzes the condensation of isopenteny...

Dimethylglycine Dehydrogenase - A FLAVOPROTEIN enzyme that catalyzes the oxidative demethylation of dimethylglycine to SARCOSINE and...

Dinitrogenase Reductase - A non-heme iron-sulfur protein isolated from Clostridium pasteurianum and other bacteria. It is a co...

Dioxygenases - Non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are i...

Dipeptidases - EXOPEPTIDASES that specifically act on dipeptides. EC 3.4.13....

Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - A subclass of exopeptidases that includes enzymes which cleave either two or three AMINO ACIDS from ...

Diphosphotransferases - A class of phosphotransferases that catalyzes the transfer of diphosphate-containing groups. EC 2.7....

Diphtheria Toxin - An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and sy...

DNA (Cytosine-5-)-Methyltransferase - An enzyme that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the 5-position ...

DNA Glycosylases - A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzin...

DNA Gyrase - A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passa...

DNA Helicases - Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to si...

DNA Ligases - Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of pre...

DNA Modification Methylases - Enzymes that are part of the restriction-modification systems. They are responsible for producing a ...

DNA Nucleotidylexotransferase - A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catal...

DNA Nucleotidyltransferases - Enzymes that catalyze the incorporation of deoxyribonucleotides into a chain of DNA. EC 2.7.7.-....

DNA Polymerase beta - A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7....

DNA Polymerase I - A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. ...

DNA Polymerase II - A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present...

DNA Polymerase III - A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present...

DNA Primase - A single-stranded DNA-dependent RNA polymerase that functions to initiate, or prime, DNA synthesis b...

DNA Repair Enzymes - Enzymes that are involved in the reconstruction of a continuous two-stranded DNA molecule without mi...

DNA Restriction Enzymes - Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cle...

DNA Restriction-Modification Enzymes - Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are...

DNA Topoisomerase IV - A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passa...

DNA Topoisomerases - Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoin...

DNA Topoisomerases, Type I - DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage ...

DNA Topoisomerases, Type I, Archaeal - Archaeal enzymes of the DNA TOPOISOMERASES, TYPE I class that catalyze ATP-independent breakage of o...

DNA Topoisomerases, Type I, Bacterial - Bacterial enzymes of the DNA TOPOISOMERASES, TYPE I class that catalyze ATP-independent breakage of ...

DNA Topoisomerases, Type I, Eukaryotic - Eukaryotic enzymes of the DNA TOPOISOMERASES, TYPE I class that catalyze ATP-independent breakage of...

DNA Topoisomerases, Type II - DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbro...

DNA Topoisomerases, Type II, Archaeal - Archaeal enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of bo...

DNA Topoisomerases, Type II, Bacterial - Bacterial enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of b...

DNA Topoisomerases, Type II, Eukaryotic - Eukaryotic enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of...

DNA-(Apurinic or Apyrimidinic Site) Lyase - A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA ...

DNA, Catalytic - Molecules of DNA that possess enzymatic activity....

DNA-Activated Protein Kinase - A serine-threonine protein kinase that, when activated by DNA, phosphorylates several DNA-binding pr...

DnaB Helicases - A family of DNA helicases that participate in DNA REPLICATION. They assemble into hexameric rings wi...

DNA-Cytosine Methylases - Methylases that are specific for CYTOSINE residues found on DNA....

DNA-Directed DNA Polymerase - DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication proc...

DNA-Directed RNA Polymerases - Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide ...

DNA-Formamidopyrimidine Glycosylase - A DNA repair enzyme that is an N-glycosyl hydrolase with specificity for DNA-containing ring-opened ...

Dopa Decarboxylase - One of the AROMATIC-L-AMINO-ACID DECARBOXYLASES, this enzyme is responsible for the conversion of do...

Dual Specificity Phosphatase 1 - A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by ina...

Dual Specificity Phosphatase 2 - A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by ina...

Dual Specificity Phosphatase 3 - A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by ina...

Dual Specificity Phosphatase 6 - A dual specificity phosphatase subtype that plays a role in intracellular signal transduction by ina...

Dual-Specificity Phosphatases - A sub-class of protein tyrosine phosphatases that contain an additional phosphatase activity which c...

D-Xylulose Reductase - An enzyme that plays a role in the PENTOSES and GLUCURONATES interconversion pathway by catalyzing t...

Dynamin I - A subtype of dynamin found primarily in the NEURONS of the brain....

Dynamin II - A subtype of dynamin found ubiquitously expressed in a variety of tissues....

Dynamin III - A subtype of dynamin found expressed exclusively in the testis, lung and brain....

Dynamins - A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport...

Dyneins - A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis to power ...

E1A-Associated p300 Protein - A member of the p300-CBP transcription factors that was originally identified as a binding partner f...

eIF-2 Kinase - A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In...

Electron Transport Chain Complex Proteins - A complex of enzymes and PROTON PUMPS located on the inner membrane of the MITOCHONDRIA and in bacte...

Electron Transport Complex I - A flavoprotein and iron sulfur-containing oxidoreductase complex that catalyzes the conversion of UB...

Electron Transport Complex II - A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCC...

Electron Transport Complex III - A multisubunit enzyme complex that contains CYTOCHROME B GROUP; CYTOCHROME C1; and iron-sulfur cente...

Electron Transport Complex IV - A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13...

Electron-Transferring Flavoproteins - Flavoproteins that serve as specific electron acceptors for a variety of DEHYDROGENASES. They partic...

Elongation Factor 2 Kinase - A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEP...

Endo-1,3(4)-beta-Glucanase - An endocellulase with specificity for the hydrolysis of 1,3- or 1,4-linkages in beta-D-glucans. This...

Endo-1,4-beta Xylanases - Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS....

Endodeoxyribonucleases - A group of enzymes catalyzing the endonucleolytic cleavage of DNA. They include members of EC 3.1.21...

Endonucleases - Enzymes that catalyze the hydrolysis of the internal bonds and thereby the formation of polynucleoti...

Endopeptidase Clp - An ATP-dependent protease found in prokaryotes, CHLOROPLASTS, and MITOCHONDRIA. It is a soluble mult...

Endopeptidase K - An enzyme that catalyzes the hydrolysis of keratin, and of other proteins with subtilisin-like speci...

Endopeptidases - A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS....

Endoribonucleases - A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3...

Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) - An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl...

Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) - An NAD-dependent enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-deh...

Enoyl-CoA Hydratase - An enzyme that catalyzes reversibly the hydration of unsaturated fatty acyl-CoA to yield beta-hydrox...

Enteropeptidase - A specialized proteolytic enzyme secreted by intestinal cells. It converts TRYPSINOGEN into its acti...

Enzymes - Biological molecules that possess catalytic activity. They may occur naturally or be synthetically c...

Enzymes, Immobilized - Enzymes which are immobilized on or in a variety of water-soluble or water-insoluble matrices with l...

Eosinophil Cationic Protein - One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic pro...

Eosinophil Peroxidase - A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a...

Eosinophil-Derived Neurotoxin - A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLE...

Epoxide Hydrolases - Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromati...

epsilon-Crystallins - A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of DUCKS and CROCODILES....

Estradiol Dehydrogenases - Enzymes that catalyze the oxidation of estradiol at the 17-hydroxyl group in the presence of NAD+ or...

Ethanolamine Ammonia-Lyase - An enzyme that catalyzes the deamination of ethanolamine to acetaldehyde. EC 4.3.1.7....

Ethanolaminephosphotransferase - An enzyme that catalyzes reversibly the transfer of phosphoethanolamine from CDP-ethanolamine to dia...

Ethylmorphine-N-Demethylase - A drug-metabolizing enzyme of the hepatic microsomal oxidase system which catalyzes the oxidation of...

Eukaryotic Initiation Factor-4A - A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the sec...

Exodeoxyribonuclease V - An ATP-dependent exodeoxyribonuclease that cleaves in either the 5'- to 3'- or the 3'- to 5'-directi...

Exodeoxyribonucleases - A family of enzymes that catalyze the exonucleolytic cleavage of DNA. It includes members of the cla...

Exonucleases - Enzymes that catalyze the release of mononucleotides by the hydrolysis of the terminal bond of deoxy...

Exopeptidases - A sub-class of PEPTIDE HYDROLASES that act only near the ends of polypeptide chains....

Exoribonucleases - A family of enzymes that catalyze the exonucleolytic cleavage of RNA. It includes EC 3.1.13.-, EC 3....

Extracellular Signal-Regulated MAP Kinases - A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation...

Factor IXa - Activated form of factor IX. This activation can take place via the intrinsic pathway by the action ...

Factor VIIa - Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagu...

Factor Xa - Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood c...

Factor XIa - Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa ...

Factor XIIa - Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, ka...

Factor XIIIa - Activated form of FACTOR XIII, a transglutaminase, which stabilizes the formation of the fibrin poly...

Fanconi Anemia Complementation Group L Protein - An E3 UBIQUITIN LIGASE that plays a key role in the DNA damage response pathway of FANCONI ANEMIA PR...

Farnesyl-Diphosphate Farnesyltransferase - The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it c...

Farnesyltranstransferase - An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diph...

Fatty Acid Desaturases - A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydro...

Fatty Acid Synthetase Complex - An enzyme complex of multiple catalytic domains which elongates FATTY ACIDS. The form found in BACTE...

Fatty Acid Synthetase Complex, Type I - Animal form of fatty acid synthase which is encoded by a single gene and consists of seven catalytic...

Fatty Acid Synthetase Complex, Type II - The form of fatty acid synthase complex found in BACTERIA; FUNGI and PLANTS. Catalytic steps are lik...

Ferredoxin-NADP Reductase - An enzyme that catalyzes the oxidation and reduction of FERREDOXIN or ADRENODOXIN in the presence of...

Ferredoxin-Nitrite Reductase - An IRON-containing protein that uses siroheme and 4Fe-4S iron-sulfur centers as prosthetic groups. I...

Ferrochelatase - A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8...

Fibrinolysin - A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of...

Ficain - A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is ...

Flap Endonucleases - Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap stru...

FMN Reductase - An enzyme that utilizes NADH or NADPH to reduce FLAVINS. It is involved in a number of biological pr...

fms-Like Tyrosine Kinase 3 - A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONC...

Focal Adhesion Kinase 1 - A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central compone...

Focal Adhesion Kinase 2 - A non-receptor protein-tyrosine kinase that is expressed primarily in the BRAIN; OSTEOBLASTS; and LY...

Focal Adhesion Protein-Tyrosine Kinases - A family of non-receptor, PROLINE-rich protein-tyrosine kinases....

Formate Dehydrogenases - Flavoproteins that catalyze reversibly the reduction of carbon dioxide to formate. Many compounds ca...

Formate-Tetrahydrofolate Ligase - A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and ...

Fructokinases - A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-...

Fructose-Bisphosphatase - An enzyme that catalyzes the conversion of D-fructose 1,6-bisphosphate and water to D-fructose 6-pho...

Fructose-Bisphosphate Aldolase - An enzyme of the lyase class that catalyzes the cleavage of fructose 1,6-biphosphate to form dihydro...

Fructuronate Reductase - An enzyme that catalyzes the reversible oxidation of mannonate to fructuronate in the presence of NA...

Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase - An enzyme that catalyzes the transfer of acetylgalactosamine from UDP N-acetylgalactosamine to vario...

Fucosyltransferases - Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecu...

Fumarate Hydratase - An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one o...

Furin - A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON W...

Fusion Proteins, bcr-abl - Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the g...

Galactokinase - An enzyme that catalyzes reversibly the formation of galactose 1-phosphate and ADP from ATP and D-ga...

Galactose Dehydrogenases - D-Galactose:NAD(P)+ 1-oxidoreductases. Catalyzes the oxidation of D-galactose in the presence of NAD...

Galactose Oxidase - An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It ...

Galactosidases - A family of galactoside hydrolases that hydrolyze compounds with an O-galactosyl linkage. EC 3.2.1.-...

Galactosylceramidase - An enzyme that hydrolyzes galactose from ceramide monohexosides. Deficiency of this enzyme may cause...

Galactosylgalactosylglucosylceramidase - An enzyme that catalyzes the hydrolysis of a ceramidetrihexoside to a ceramidedihexoside plus galact...

Galactosyltransferases - Enzymes that catalyze the transfer of galactose from a nucleoside diphosphate galactose to an accept...

gamma-Butyrobetaine Dioxygenase - An enzyme that catalyzes the HYDROXYLATION of gamma-butyrobetaine to L-CARNITINE. It is the last enz...

gamma-Glutamyl Hydrolase - Catalyzes the hydrolysis of pteroylpolyglutamic acids in gamma linkage to pterolylmonoglutamic acid ...

gamma-Glutamylcyclotransferase - An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also relea...

gamma-Glutamyltransferase - An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (G...

Ganglioside Galactosyltransferase - Catalyzes the final step in the galactocerebroside biosynthesis pathway....

Gelatinases - A class of enzymes that catalyzes the degradation of gelatin by acting on the peptide bonds. EC 3.4....

Geranylgeranyl-Diphosphate Geranylgeranyltransferase - An enzyme that catalyzes the condensation of two molecules of geranylgeranyl diphosphate to give pre...

Geranyltranstransferase - An enzyme involved in the MEVALONATE pathway, it catalyses the synthesis of farnesyl diphosphate fro...

Glucan 1,3-beta-Glucosidase - An exocellulase with specificity for 1,3-beta-D-glucasidic linkages. It catalyzes hydrolysis of beta...

Glucan 1,4-alpha-Glucosidase - An enzyme that catalyzes the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively...

Glucan 1,4-beta-Glucosidase - An exocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages of 1,4-beta-D-gl...

Glucan Endo-1,3-beta-D-Glucosidase - An endocellulase with specificity for the hydrolysis of 1,3-beta-D-glucosidic linkages in 1,3-beta-D...

Glucokinase - A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phospha...

Glucosamine 6-Phosphate N-Acetyltransferase - An enzyme that catalyses the reaction of D-glucosamine 6-phosphate with ACETYL-COA to form N-acetylg...

Glucose 1-Dehydrogenase - A glucose dehydrogenase that catalyzes the oxidation of beta-D-glucose to form D-glucono-1,5-lactone...

Glucose Dehydrogenases - D-Glucose:1-oxidoreductases. Catalyzes the oxidation of D-glucose to D-glucono-gamma-lactone and red...

Glucose Oxidase - An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to ...

Glucose-1-Phosphate Adenylyltransferase - An ATP-dependent enzyme that catalyzes the addition of ADP to alpha-D-glucose 1-phosphate to form AD...

Glucose-6-Phosphatase - An enzyme that catalyzes the conversion of D-glucose 6-phosphate and water to D-glucose and orthopho...

Glucose-6-Phosphate Isomerase - An enzyme that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosph...

Glucosidases - Enzymes that hydrolyze O-glucosyl-compounds. (Enzyme Nomenclature, 1992) EC 3.2.1.-....

Glucosylceramidase - A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of ...

Glucosyltransferases - Enzymes that catalyze the transfer of glucose from a nucleoside diphosphate glucose to an acceptor m...

Glucuronosyltransferase - A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and f...

Glutamate Carboxypeptidase II - A metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes t...

Glutamate Decarboxylase - A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form ga...

Glutamate Dehydrogenase - An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the pr...

Glutamate Dehydrogenase (NADP+) - An enzyme that catalyzes the conversion of L-glutamate, H2O, and NADP+ to 2-oxoglutarate, NH3, and N...

Glutamate Formimidoyltransferase - A PYRIDOXAL PHOSPHATE-containing enzyme that catalyzes the transfer of a formyl group from L-GLUTAMA...

Glutamate Synthase - An enzyme that catalyzes the formation of 2 molecules of glutamate from glutamine plus alpha-ketoglu...

Glutamate Synthase (NADH) - A FLAVOPROTEIN enzyme for AMMONIA assimilation in BACTERIA, microorganisms and PLANTS. It catalyzes ...

Glutamate-5-Semialdehyde Dehydrogenase - An NADP+ dependent enzyme that catalyzes the oxidation of L-glutamate 5-semialdehyde to L-glutamyl 5...

Glutamate-Ammonia Ligase - An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-g...

Glutamate-Cysteine Ligase - One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylc...

Glutamate-tRNA Ligase - An enzyme that activates glutamic acid with its specific transfer RNA. EC 6.1.1.17....

Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - An enzyme that catalyzes the synthesis of fructose-6-phosphate plus GLUTAMINE from GLUTAMATE plus gl...

Glutamyl Aminopeptidase - A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLU...

Glutaredoxins - A family of thioltransferases that contain two active site CYSTEINE residues, which either form a di...

Glutaryl-CoA Dehydrogenase - A flavoprotein enzyme that is responsible for the catabolism of LYSINE; HYDROXYLYSINE; and TRYPTOPHA...

Glutathione Peroxidase - An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to...

Glutathione Reductase - Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency...

Glutathione S-Transferase pi - A glutathione transferase that catalyzes the conjugation of electrophilic substrates to GLUTATHIONE....

Glutathione Synthase - One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of glutathione fro...

Glutathione Transferase - A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as w...

Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) - An NADP-dependent, non-phosphorylating aldehyde dehydrogenase that catalyzes the irreversible oxidat...

Glyceraldehyde-3-Phosphate Dehydrogenase (NADP+)(Phosphorylating) - A phosphorylating glyceraldehyde-3-phosphate dehydrogenase found in the CHLOROPLASTS of higher plant...

Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - An NAD-dependent glyceraldehyde-3-phosphate dehydrogenase found in the cytosol of eucaryotes. It cat...

Glyceraldehyde-3-Phosphate Dehydrogenases - Enzymes that catalyze the dehydrogenation of GLYCERALDEHYDE 3-PHOSPHATE. Several types of glyceralde...

Glycerol Kinase - An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyaceto...

Glycerol-3-Phosphate Dehydrogenase (NAD+) - An NAD-dependent enzyme that catalyzes the oxidation of sn-glycerol 3-phosphate to glycerone phospha...

Glycerol-3-Phosphate O-Acyltransferase - An enzyme that transfers acyl groups from acyl-CoA to glycerol-3-phosphate to form monoglyceride pho...

Glycerophosphoinositol Inositolphosphodiesterase - A phosphoric diester hydrolase with specificity for the cleavage of GLYCEROL from 1-(sn-glycero-3-ph...

Glycine Decarboxylase Complex - A enzyme complex that catalyzes the oxidative DECARBOXYLATION and DEAMINATION of GLYCINE into CARBON...

Glycine Decarboxylase Complex H-Protein - A LIPOIC ACID-containing protein that plays the pivotal role in the transfer of methylamine groups a...

Glycine Dehydrogenase - An oxidoreductase that catalyzes the oxidative DEAMINATION of GLYCINE to glyoxylate and AMMONIA in t...

Glycine Dehydrogenase (Decarboxylating) - A PYRIDOXAL PHOSPHATE dependent enzyme that catalyzes the decarboxylation of GLYCINE with the transf...

Glycine Hydroxymethyltransferase - A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofol...

Glycine N-Methyltransferase - An enzyme that catalyzes the METHYLATION of GLYCINE using S-ADENOSYLMETHIONINE to form SARCOSINE wit...

Glycine Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of GLYCINE onto 2...

Glycine-tRNA Ligase - An enzyme that activates glycine with its specific transfer RNA. EC 6.1.1.14....

Glycogen Debranching Enzyme System - 1,4-alpha-D-Glucan-1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase/dextrin 6 alpha-D-glucanohydrola...

Glycogen Phosphorylase - An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate fro...

Glycogen Phosphorylase, Brain Form - An isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in brain tissue....

Glycogen Phosphorylase, Liver Form - An isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in liver tissue. M...

Glycogen Phosphorylase, Muscle Form - An isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in muscle. Mutatio...

Glycogen Synthase - An enzyme that catalyzes the transfer of D-glucose from UDPglucose into 1,4-alpha-D-glucosyl chains....

Glycogen Synthase Kinase 3 - A glycogen synthase kinase that was originally described as a key enzyme involved in glycogen metabo...

Glycogen Synthase Kinases - A class of protein-serine-threonine kinases that was originally found as one of the three types of k...

Glycogen-Synthase-D Phosphatase - An enzyme that catalyzes the conversion of phosphorylated, inactive glycogen synthase D to active de...

Glycolaldehyde Dehydrogenase - An enzyme that catalyzes the oxidation of glycolaldehyde to glycolate, using NAD and NADP as COENZYM...

Glycosylceramidase - The enzyme hydrolyzing glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. It also catalyze...

Glycosylphosphatidylinositol Diacylglycerol-Lyase - A type C phospholipase specific for GLYCOSYLPHOSPHATIDYLINOSITOLS. It plays a role in the breaking o...

Glycosyltransferases - Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrat...

GMP Reductase - An enzyme that catalyzes the reversible oxidation of inosine 5'-phosphate (IMP) to guanosine 5'-phos...

G-Protein-Coupled Receptor Kinase 1 - A PROTEIN-SERINE-THREONINE KINASE that is found in PHOTORECEPTOR CELLS. It mediates light-dependent ...

G-Protein-Coupled Receptor Kinase 2 - A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agon...

G-Protein-Coupled Receptor Kinase 3 - A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agon...

G-Protein-Coupled Receptor Kinase 4 - A G-protein-coupled receptor kinase subtype that is primarily expressed in the TESTES and BRAIN. Var...

G-Protein-Coupled Receptor Kinase 5 - A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may pl...

G-Protein-Coupled Receptor Kinases - A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. They are reg...

Granzymes - A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-...

Group I Chaperonins - A subcategory of chaperonins found in MITOCHONDRIA; CHLOROPLASTS; and BACTERIA. Group I chaperonins ...

Group I Phospholipases A2 - A subcategory of secreted phospholipases A2 that includes enzymes isolated from ELAPID VENOMS and pa...

Group IA Phospholipases A2 - A subclass of group I phospholipases A2 that includes enzymes isolated from ELAPID VENOMS....

Group IB Phospholipases A2 - A subclass of group I phospholipases A2 that includes enzymes isolated from PANCREATIC JUICE. Member...

Group II Chaperonins - A subcategory of chaperonins found in ARCHAEA and the CYTOSOL of eukaryotic cells. Group II chaperon...

Group II Phospholipases A2 - A subcategory of secreted phospholipases A2 that includes enzymes isolated from a variety of sources...

Group III Histone Deacetylases - A subclass of histone deacetylases that are NAD-dependent. Several members of the SIRTUINS family ar...

Group III Phospholipases A2 - A subcategory of secreted phospholipases A2 with specificity for PHOSPHATIDYLETHANOLAMINES and PHOSP...

Group IV Phospholipases A2 - A cytosolic phospholipase A2 group that plays an important role in the release of free ARACHIDONIC A...

Group V Phospholipases A2 - A subcategory of secreted phospholipases A2 that contains both a negatively charged carboxy-terminal...

Group VI Phospholipases A2 - A calcium-independent phospholipase A2 group that may play a role in membrane phospholipid remodelin...

Group X Phospholipases A2 - A secreted phospholipase A2 subtype that contains a interfacial-binding region with specificity for ...

GTP Cyclohydrolase - (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). A...

GTP Phosphohydrolase-Linked Elongation Factors - Factors that utilize energy from the hydrolysis of GTP to GDP for peptide chain elongation. EC 3.6.1...

GTP Phosphohydrolases - Enzymes that hydrolyze GTP to GDP. EC 3.6.1.-....

GTP Pyrophosphokinase - An enzyme that catalyzes reversibly the transfer of a pyrophosphate group from ATP to the 3'-OH grou...

GTP-Binding Protein alpha Subunit, Gi2 - A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SUR...

GTP-Binding Protein alpha Subunits - The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the het...

GTP-Binding Protein alpha Subunits, G12-G13 - A ubiquitously expressed family of heterotrimeric GTP-binding protein alpha subunits that signal thr...

GTP-Binding Protein alpha Subunits, Gi-Go - A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by the...

GTP-Binding Protein alpha Subunits, Gq-G11 - A family of heterotrimeric GTP-binding protein alpha subunits that activate TYPE C PHOSPHOLIPASES de...

GTP-Binding Protein alpha Subunits, Gs - A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLATE CYCLASE....

GTP-Binding Proteins - Regulatory proteins that act as molecular switches. They control a wide range of biological processe...

Guanidinoacetate N-Methyltransferase - This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanid...

Guanine Deaminase - An enzyme that catalyzes the deamination of guanine to form xanthine. EC 3.5.4.3....

Guanylate Cyclase - An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts o...

Guanylate Kinase - Catalyzes the ATP-dependent PHOSPHORYLATION of GMP to generate GDP and ADP....

H(+)-K(+)-Exchanging ATPase - An enzyme isolated from the gastric mucosa that catalyzes the hydrolysis of ATP coupled with the exc...

Heme Oxygenase (Decyclizing) - A mixed function oxidase enzyme which during hemoglobin catabolism catalyzes the degradation of heme...

Heme Oxygenase-1 - A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; C...

Heparin Lyase - An enzyme of the isomerase class that catalyzes the eliminative cleavage of polysaccharides containi...

Heterotrimeric GTP-Binding Proteins - GTP-BINDING PROTEINS that contain three non-identical subunits. They are found associated with membe...

Hexokinase - An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-G...

Hexosaminidase A - A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminida...

Hexosaminidase B - A mammalian beta-hexosaminidase isoform that is comprized of hexosaminidase beta subunits. Deficienc...

Hexosaminidases - Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminida...

Hexosyltransferases - Enzymes that catalyze the transfer of hexose groups. EC 2.4.1.-....

Histamine N-Methyltransferase - An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, form...

Histidine Ammonia-Lyase - An enzyme that catalyzes the first step of histidine catabolism, forming UROCANIC ACID and AMMONIA f...

Histidine Decarboxylase - An enzyme that catalyzes the decarboxylation of histidine to histamine and carbon dioxide. It requir...

Histidine-tRNA Ligase - An enzyme that activates histidine with its specific transfer RNA. EC 6.1.1.21....

Histidinol-Phosphatase - An enzyme that catalyzes the hydrolysis of histidinol-phosphate to histidinol. One of the regulatory...

Histone Acetyltransferases - Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histone...

Histone Deacetylase 1 - A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 2; RETINOBLASTOMA-BINDING...

Histone Deacetylase 2 - A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING...

Histone Deacetylases - Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The ...

Histone Demethylases - Enzymes that catalyse the removal of methyl groups from LYSINE or ARGININE residues found on HISTONE...

Histone-Lysine N-Methyltransferase - An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins t...

HIV Integrase - Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA...

HIV Protease - Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag a...

HIV Reverse Transcriptase - A reverse transcriptase encoded by the POL GENE of HIV. It is a heterodimer of 66 kDa and 51 kDa sub...

Holliday Junction Resolvases - Enzymes that recognize CRUCIFORM DNA structures and introduce paired incisions that help to resolve ...

Holoenzymes - Catalytically active enzymes that are formed by the combination of an apoenzyme (APOENZYMES) and its...

Homocysteine S-Methyltransferase - An enzyme that catalyzes the demethylation of L-homocysteine to L-METHIONINE....

Homogentisate 1,2-Dioxygenase - A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4...

Homoserine Dehydrogenase - An enzyme that catalyzes the reduction of aspartic beta-semialdehyde to homoserine, which is the bra...

Homoserine O-Succinyltransferase - The first enzyme in the METHIONINE biosynthetic pathway, this enzyme catalyzes the succinylation rea...

Horseradish Peroxidase - An enzyme isolated from horseradish which is able to act as an antigen. It is frequently used as a h...

Hyaluronoglucosaminidase - An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine a...

Hydrogenase - An enzyme found in bacteria. It catalyzes the reduction of FERREDOXIN and other substances in the pr...

Hydrogensulfite Reductase - An enzyme found primarily in SULFUR-REDUCING BACTERIA where it plays an important role in the anaero...

Hydrolases - Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of w...

Hydro-Lyases - Enzymes that catalyze the breakage of a carbon-oxygen bond leading to unsaturated products via the r...

Hydroxymethyl and Formyl Transferases - Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. EC 2.1.2....

Hydroxymethylbilane Synthase - An enzyme that catalyzes the tetrapolymerization of the monopyrrole PORPHOBILINOGEN into the hydroxy...

Hydroxymethylglutaryl CoA Reductases - Enzymes that catalyze the reversible reduction of alpha-carboxyl group of 3-hydroxy-3-methylglutaryl...

Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes p...

Hydroxymethylglutaryl-CoA Synthase - An enzyme that catalyzes the synthesis of hydroxymethylglutaryl-CoA from acetyl-CoA and acetoacetyl-...

Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent - Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of thi...

Hydroxyprostaglandin Dehydrogenases - Catalyzes reversibly the oxidation of hydroxyl groups of prostaglandins....

Hydroxypyruvate Reductase - An enzyme that catalyzes the oxidation of D-glycerate to hydroxypyruvate in the presence of NADP....

Hydroxysteroid Dehydrogenases - Enzymes of the oxidoreductase class that catalyze the dehydrogenation of hydroxysteroids. (From Enzy...

Hypoxanthine Phosphoribosyltransferase - An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanin...

Iduronate Sulfatase - An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demo...

Iduronidase - An enzyme that hydrolyzes iduronosidic linkages in desulfated dermatan. Deficiency of this enzyme pr...

I-kappa B Kinase - A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enz...

Immunophilins - Members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases ...

IMP Dehydrogenase - An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in t...

Indole-3-Glycerol-Phosphate Synthase - An enzyme in the tryptophan biosynthetic pathway. EC 4.1.1.48....

Indoleamine-Pyrrole 2,3,-Dioxygenase - A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is an ext...

Inorganic Pyrophosphatase - An enzyme which catalyzes the hydrolysis of diphosphate (DIPHOSPHATES) into inorganic phosphate. The...

Inositol Oxygenase - A non-heme IRON enzyme that catalyzes the conversion of MYOINOSITOL to D-glucuronic acid. The reacti...

Insulysin - An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited...

Integrases - Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by th...

Interleukin-1 Receptor-Associated Kinases - A family of intracellular signaling kinases that were identified by their ability to signal from the...

Intramolecular Lyases - Enzymes of the isomerase class that catalyze reactions in which a group can be regarded as eliminate...

Intramolecular Oxidoreductases - Enzymes of the isomerase class that catalyze the oxidation of one part of a molecule with a correspo...

Intramolecular Transferases - Enzymes of the isomerase class that catalyze the transfer of acyl-, phospho-, amino- or other groups...

Iodide Peroxidase - A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodin...

Iron Regulatory Protein 1 - A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form o...

Iron Regulatory Protein 2 - A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form o...

Isoamylase - An enzyme that hydrolyzes 1,6-alpha-glucosidic branch linkages in glycogen, amylopectin, and their b...

Isocitrate Dehydrogenase - An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield ...

Isocitrate Lyase - A key enzyme in the glyoxylate cycle. It catalyzes the conversion of isocitrate to succinate and gly...

Isoenzymes - Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, b...

Isoleucine-tRNA Ligase - An enzyme that activates isoleucine with its specific transfer RNA. EC 6.1.1.5....

Isomerases - A class of enzymes that catalyze geometric or structural changes within a molecule to form a single ...

Isovaleryl-CoA Dehydrogenase - A mitochondrial flavoprotein, this enzyme catalyzes the oxidation of 3-methylbutanoyl-CoA to 3-methy...

Janus Kinase 1 - A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS....

Janus Kinase 2 - A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPT...

Janus Kinase 3 - A Janus kinase subtype that is predominantly expressed in hematopoietic cell. It is involved in sign...

Janus Kinases - A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by...

JNK Mitogen-Activated Protein Kinases - A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phos...

Jumonji Domain-Containing Histone Demethylases - A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via a...

Kallikreins - Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifical...

Kanamycin Kinase - A class of enzymes that inactivate aminocyclitol-aminoglycoside antibiotics (AMINOGLYCOSIDES) by reg...

Ketol-Acid Reductoisomerase - An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-met...

Ketone Oxidoreductases - Oxidoreductases that are specific for KETONES....

Kinesin - A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis...

Kynurenine 3-Monooxygenase - An NADPH-dependent flavin monooxygenase that plays a key role in the catabolism of TRYPTOPHAN by cat...

Laccase - A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzose...

Lactase - An enzyme which catalyzes the hydrolysis of LACTOSE to D-GALACTOSE and D-GLUCOSE. Defects in the enz...

Lactate Dehydrogenases - Alcohol oxidoreductases with substrate specificity for LACTIC ACID....

Lactoperoxidase - An enzyme derived from cow's milk. It catalyzes the radioiodination of tyrosine and its derivatives ...

Lactose Synthase - An enzyme of the transferase class that catalyzes the transfer of galactose from UDPgalactose to glu...

Lactoylglutathione Lyase - An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving ...

L-Amino Acid Oxidase - An enzyme that catalyzes the oxidative deamination of L-amino acids to KETO ACIDS with the generatio...

L-Aminoadipate-Semialdehyde Dehydrogenase - An enzyme that catalyzes the oxidation of L-2-aminoadipate 6-semialdehyde to L-2-aminoadipate (alph...

Leucine Dehydrogenase - An octameric enzyme belonging to the superfamily of amino acid dehydrogenases. Leucine dehydrogenase...

Leucine Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-cha...

Leucine-tRNA Ligase - An enzyme that activates leucine with its specific transfer RNA. EC 6.1.1.4....

Leucyl Aminopeptidase - A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino a...

Leukocyte Elastase - An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bo...

L-Gulonolactone Oxidase - An enzyme involved in the metabolism of ASCORBIC ACID and aldarate. It catalyzes the oxidation of L-...

L-Iditol 2-Dehydrogenase - An alcohol oxidoreductase which catalyzes the oxidation of L-iditol to L-sorbose in the presence of ...

Ligases - A class of enzymes that catalyze the formation of a bond between two substrate molecules, coupled wi...

Light-Harvesting Protein Complexes - Complexes containing CHLOROPHYLL and other photosensitive molecules. They serve to capture energy in...

Lim Kinases - Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembl...

Linoleoyl-CoA Desaturase - An enzyme that catalyzes the syn-dehydrogenation of linoleol-CoA gamma-linolenoyl-CoA. It was former...

Lipase - An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield d...

Lipoprotein Lipase - An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield d...

Lipoxygenase - An enzyme of the oxidoreductase class that catalyzes reactions between linoleate and other fatty aci...

L-Lactate Dehydrogenase - A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and...

L-Lactate Dehydrogenase (Cytochrome) - A cytochrome form of lactate dehydrogenase found in the MITOCHONDRIA. It catalyzes the oxidation of ...

L-Lysine 6-Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-LYSINE onto ...

L-Serine Dehydratase - A PYRIDOXAL-phosphate containing enzyme that catalyzes the dehydration and deamination of L-serine t...

Luciferases - Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferas...

Lyases - A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means t...

Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - This enzyme is a lymphoid-specific src family tyrosine kinase that is critical for T-cell developmen...

Lysine Carboxypeptidase - A metallocarboxypeptidase that removes C-terminal basic amino acid from peptides and proteins, with ...

Lysine-tRNA Ligase - An enzyme that activates lysine with its specific transfer RNA. EC 6.1.1.6....

Lysophospholipase - An enzyme that catalyzes the hydrolysis of a single fatty acid ester bond in lysoglycerophosphatidat...

Lysostaphin - A 25-kDa peptidase produced by Staphylococcus simulans which cleaves a glycine-glcyine bond unique t...

Malate Dehydrogenase - An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37...

Malate Dehydrogenase (NADP+) - A light-activated enzyme that catalyzes the oxidation of (S)-malate to OXALOACETATE. It is involved ...

Malate Synthase - An important enzyme in the glyoxylic acid cycle which reversibly catalyzes the synthesis of L-malate...

Malonate-Semialdehyde Dehydrogenase (Acetylating) - An enzyme that catalyzes the oxidation of 3-oxopropanoate (malonate semialdehyde) to acetyl COENZYME...

Mannitol Dehydrogenases - Sugar alcohol dehydrogenases that have specificity for MANNITOL. Enzymes in this category are genera...

Mannose-6-Phosphate Isomerase - An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-...

Mannose-Binding Protein-Associated Serine Proteases - Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed...

Mannosidases - Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE....

Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase - A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in ...

Mannosyltransferases - Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor m...

MAP Kinase Kinase 1 - An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTI...

MAP Kinase Kinase 2 - A 44 kDa mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINA...

MAP Kinase Kinase 3 - A mitogen-activated protein kinase kinase with specificity for a subset of P38 MITOGEN-ACTIVATED PR...

MAP Kinase Kinase 4 - A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES...

MAP Kinase Kinase 5 - A mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 7....

MAP Kinase Kinase 6 - A mitogen-activated protein kinase kinase with specificity for P38 MITOGEN-ACTIVATED PROTEIN KINASES...

MAP Kinase Kinase 7 - A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES...

MAP Kinase Kinase Kinase 1 - A 195-kDa MAP kinase kinase kinase with broad specificity for MAP KINASE KINASES. It is found locali...

MAP Kinase Kinase Kinase 2 - A 70-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 5. It is activated during t...

MAP Kinase Kinase Kinase 3 - A 70-kDa MAPK kinase kinase with specificity for MAP KINASE KINASE 5....

MAP Kinase Kinase Kinase 4 - A 180-kDa MAP kinase kinase kinase with specificity for MAP KINASE KINASE 4 and MAP KINASE KINASE 6....

MAP Kinase Kinase Kinase 5 - A 150-kDa MAP kinase kinase kinase that may play a role in the induction of APOPTOSIS. It has specif...

MAP Kinase Kinase Kinases - Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that ...

Matrix Metalloproteinase 1 - A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIB...

Matrix Metalloproteinase 10 - A secreted matrix metalloproteinase that may play a role in matrix degradation during WOUND HEALING....

Matrix Metalloproteinase 11 - A secreted matrix metalloproteinase that is believed to play a role in EXTRACELLULAR MATRIX remodeli...

Matrix Metalloproteinase 12 - A secreted matrix metalloproteinase which is highly expressed by MACROPHAGES where it may play a rol...

Matrix Metalloproteinase 13 - A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellu...

Matrix Metalloproteinase 14 - A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen...

Matrix Metalloproteinase 15 - A transmembrane domain-containing matrix metalloproteinase that plays a role in the cleavage of prot...

Matrix Metalloproteinase 16 - A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen...

Matrix Metalloproteinase 17 - A membrane-type metalloproteinase that is associated with the CELL MEMBRANE via a GLYCOSYL-PHOSPHATI...

Matrix Metalloproteinase 2 - A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional...

Matrix Metalloproteinase 20 - A secreted matrix metalloproteinase that is the predominant proteolytic activity in the enamel matri...

Matrix Metalloproteinase 3 - An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It diges...

Matrix Metalloproteinase 7 - The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression....

Matrix Metalloproteinase 8 - A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III....

Matrix Metalloproteinase 9 - An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN typ...

Matrix Metalloproteinases - A family of zinc-dependent metalloendopeptidases that are involved in the degradation of EXTRACELLUL...

Matrix Metalloproteinases, Membrane-Associated - Matrix metalloproteinases that are associated with the CELL MEMBRANE, either through transmembrane d...

Matrix Metalloproteinases, Secreted - A subclass of matrix metalloproteinases that are secreted into the pericellular space....

Maturation-Promoting Factor - Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meios...

Metalloendopeptidases - ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism....

Metalloexopeptidases - EXOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism....

Metalloproteases - Proteases which use a metal, normally ZINC, in the catalytic mechanism. This group of enzymes is ina...

Methenyltetrahydrofolate Cyclohydrolase - An aminohydrolase that catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahy...

Methionine Adenosyltransferase - An enzyme that catalyzes the synthesis of S-adenosylmethionine from methionine and ATP. EC 2.5.1.6....

Methionine Sulfoxide Reductases - Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce pept...

Methionine-tRNA Ligase - An enzyme that activates methionine with its specific transfer RNA. EC 6.1.1.10....

Methylenetetrahydrofolate Dehydrogenase (NAD+) - A NAD-dependent oxidoreductase that catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5,...

Methylenetetrahydrofolate Dehydrogenase (NADP) - An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5...

Methylenetetrahydrofolate Reductase (NADPH2) - A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofo...

Methylmalonate-Semialdehyde Dehydrogenase (Acylating) - An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing ...

Methylmalonyl-CoA Decarboxylase - A carboxy-lyase that catalyzes the decarboxylation of (S)-2-Methyl-3-oxopropanoyl-CoA to propanoyl-...

Methylmalonyl-CoA Mutase - An enzyme that catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carb...

Methyltransferases - A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one...

Mi-2 Nucleosome Remodeling and Deacetylase Complex - A enzyme complex involved in the remodeling of NUCLEOSOMES. The complex is comprised of at least se...

Microbial Collagenase - A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred ...

Micrococcal Nuclease - An enzyme that catalyzes the endonucleolytic cleavage to 3'-phosphomononucleotide and 3'-phospholigo...

Mitochondrial Proton-Translocating ATPases - Proton-translocating ATPases responsible for ADENOSINE TRIPHOSPHATE synthesis in the MITOCHONDRIA. T...

Mitogen-Activated Protein Kinase 1 - A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell ...

Mitogen-Activated Protein Kinase 10 - A c-jun amino-terminal kinase that is found predominantly within NEURONS of the BRAIN, suggesting a ...

Mitogen-Activated Protein Kinase 3 - A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulatio...

Mitogen-Activated Protein Kinase 6 - A 97-kDa extracellular signal-regulated MAP kinase. Mitogen-activated protein kinase 6 levels increa...

Mitogen-Activated Protein Kinase 7 - A 110-kDa extracellular signal-regulated MAP kinase that is activated in response to cellular stress...

Mitogen-Activated Protein Kinase 8 - A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokin...

Mitogen-Activated Protein Kinase 9 - A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokin...

Mitogen-Activated Protein Kinase Kinases - A serine-threonine protein kinase family whose members are components in protein kinase cascades act...

Mitogen-Activated Protein Kinase Phosphatases - A subcategory of phosphohydrolases that are specific for MITOGEN-ACTIVATED PROTEIN KINASES. They pla...

Mitogen-Activated Protein Kinases - A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein ...

Mixed Function Oxygenases - Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxy...

Molecular Motor Proteins - Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor)...

Molybdoferredoxin - A non-heme iron-sulfur protein isolated from Clostridium pasteurianum and other bacteria. It is a co...

Monoacylglycerol Lipases - An enzyme that catalyzes the hydrolysis of glycerol monoesters of long-chain fatty acids EC 3.1.1.23...

Monoamine Oxidase - An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin...

Monomeric GTP-Binding Proteins - A class of monomeric, low molecular weight (20-25 kDa) GTP-binding proteins that regulate a variety ...

Monophenol Monooxygenase - An enzyme of the oxidoreductase class that catalyzes the reaction between L-tyrosine, L-dopa, and ox...

Multienzyme Complexes - Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common ...

Muramidase - A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as ...

Muramoylpentapeptide Carboxypeptidase - Enzyme which catalyzes the peptide cross-linking of nascent CELL WALL; PEPTIDOGLYCAN....

MutS DNA Mismatch-Binding Protein - A methyl-directed mismatch DNA REPAIR protein that has weak ATPASE activity. MutS was originally des...

MutS Homolog 2 Protein - MutS homolog 2 protein is found throughout eukaryotes and is a homolog of the MUTS DNA MISMATCH-BIND...

Myeloblastin - A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRON...

Myo-Inositol-1-Phosphate Synthase - An enzyme that catalyzes the formation of myo-inositol-1-phosphate from glucose-6-phosphate in the p...

Myosin Type I - A subclass of myosins found generally associated with actin-rich membrane structures such as filopod...

Myosin Type II - The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involve...

Myosin Type III - A subclass of myosins originally found in the photoreceptor of DROSOPHILA. The heavy chains can occu...

Myosin Type IV - A subclass of myosin found in ACANTHAMOEBA. It is a non-filamentous myosin containing a single 180-k...

Myosin Type V - A subclass of myosin involved in organelle transport and membrane targeting. It is abundantly found ...

Myosin-Light-Chain Kinase - An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain...

Myosin-Light-Chain Phosphatase - A phosphoprotein phosphatase that is specific for MYOSIN LIGHT CHAINS. It is composed of three subun...

Myosins - A diverse superfamily of proteins that function as translocating proteins. They share the common cha...

N-Acetylgalactosamine-4-Sulfatase - An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosami...

N-Acetylgalactosaminyltransferases - Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylga...

N-Acetylglucosaminyltransferases - Enzymes that catalyze the transfer of N-acetylglucosamine from a nucleoside diphosphate N-acetylgluc...

N-Acetylhexosaminyltransferases - Enzymes that catalyze the transfer of N-acetylhexosaminyl groups to an acceptor molecule which is fr...

N-Acetyllactosamine Synthase - The A protein of the lactose synthase complex. In the presence of the B protein (LACTALBUMIN) specif...

N-Acetylmuramoyl-L-alanine Amidase - An autolytic enzyme bound to the surface of bacterial cell walls. It catalyzes the hydrolysis of the...

N-Acylneuraminate Cytidylyltransferase - An enzyme that forms CMP-acylneuraminic acids, which donate the N-acylneuraminic acid residues to th...

N-Acylsphingosine Galactosyltransferase - An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylcerami...

NAD(P)H Dehydrogenase (Quinone) - A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxid...

NAD+ Nucleosidase - An enzyme that catalyzes the hydrolysis of nicotinamide adenine dinucleotide (NAD) to NICOTINAMIDE a...

NADH Dehydrogenase - A flavoprotein and iron sulfur-containing oxidoreductase that catalyzes the oxidation of NADH to NAD...

NADH Tetrazolium Reductase - Catalyzes the reduction of tetrazolium compounds in the presence of NADH....

NADH, NADPH Oxidoreductases - A group of oxidoreductases that act on NADH or NADPH. In general, enzymes using NADH or NADPH to red...

NADP Transhydrogenase - An enzyme present in the mitochondrial membrane of animals and in microorganisms. In the presence of...

NADPH Dehydrogenase - A flavoprotein that reversibly oxidizes NADPH to NADP and a reduced acceptor. EC 1.6.99.1....

NADPH Oxidase - A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron do...

NADPH-Ferrihemoprotein Reductase - A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of...

Naphthol AS D Esterase - Hydrolytic enzyme activity used as a histocytochemical test for the presence of esterases in tissue....

Neprilysin - Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser ...

N-Ethylmaleimide-Sensitive Proteins - ATPases that are members of the AAA protein superfamily (ATPase family Associated with various cellu...

Neuraminidase - An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages ...

Neuroleukin - Neuronal growth factor and lymphokine product of lectin-stimulated T-cells which induces immunoglobu...

Neutral Ceramidase - A ceramidase subtype that is active at neutral pH. It is found at high levels within the SMALL INTES...

N-Glycosyl Hydrolases - A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars....

Nicotinamidase - An enzyme that catalyzes the hydrolysis of nicotinamide to nicotinate and ammonia. EC 3.5.1.19....

Nicotinamide N-Methyltransferase - An enzyme found primarily in the LIVER that catalyzes the N-methylation of NICOTINAMIDE and other st...

Nicotinamide Phosphoribosyltransferase - An enzyme that catalyzes the formation of nicotinamide mononucleotide (NMN) from nicotinamide and 5-...

Nicotinamide-Nucleotide Adenylyltransferase - An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl gro...

Nitrate Reductase - An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contai...

Nitrate Reductase (NAD(P)H) - An iron-sulfur and MOLYBDENUM containing FLAVOPROTEIN that catalyzes the oxidation of nitrite to nit...

Nitrate Reductase (NADH) - An NAD-dependent enzyme that catalyzes the oxidation of nitrite to nitrate. It is a FLAVOPROTEIN tha...

Nitrate Reductase (NADPH) - An enzyme that catalyzes the oxidation of nitrite to nitrate in the presence of NADP+. It is a FLAVO...

Nitrate Reductases - Oxidoreductases that are specific for the reduction of NITRATES....

Nitric Oxide Synthase - An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLI...

Nitric Oxide Synthase Type I - A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE...

Nitric Oxide Synthase Type II - A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It i...

Nitric Oxide Synthase Type III - A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOT...

Nitrite Reductase (NAD(P)H) - An enzyme found primarily in BACTERIA and FUNGI that catalyzes the oxidation of ammonium hydroxide t...

Nitrite Reductases - A group of enzymes that oxidize diverse nitrogenous substances to yield nitrite. (Enzyme Nomenclatur...

Nitroanisole O-Demethylase - Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol....

Nitrogenase - An enzyme system that catalyzes the fixing of nitrogen in soil bacteria and blue-green algae (CYANOB...

Nitrogenous Group Transferases - Enzymes that catalyze the transfer of nitrogenous groups, primarily amino groups, from a donor, gene...

Nitroreductases - Enzymes which reduce nitro groups (NITRO COMPOUNDS) and other nitrogenous compounds....

NM23 Nucleoside Diphosphate Kinases - A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathw...

Nonmuscle Myosin Type IIA - A nonmuscle isoform of myosin type II found predominantly in platelets, lymphocytes, neutrophils and...

Nonmuscle Myosin Type IIB - A nonmuscle isoform of myosin type II found predominantly in neuronal tissue....

Nuclear Receptor Coactivator 1 - A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and ...

Nuclear Receptor Coactivator 3 - A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. I...

Nucleoside Deaminases - Catalyze the hydrolysis of nucleosides with the elimination of ammonia....

Nucleoside-Diphosphate Kinase - An enzyme that is found in mitochondria and in the soluble cytoplasm of cells. It catalyzes reversib...

Nucleoside-Phosphate Kinase - An enzyme that catalyzes reversible reactions of a nucleoside triphosphate, e.g., ATP, with a nucleo...

Nucleoside-Triphosphatase - An enzyme which catalyzes the hydrolysis of nucleoside triphosphates to nucleoside diphosphates. It ...

Nucleotidases - A class of enzymes that catalyze the conversion of a nucleotide and water to a nucleoside and orthop...

Nucleotide Deaminases - Catalyze the hydrolysis of nucleotides with the elimination of ammonia....

Nucleotidyltransferases - A class of enzymes that transfers nucleotidyl residues. EC 2.7.7....

O(6)-Methylguanine-DNA Methyltransferase - An enzyme that transfers methyl groups from O(6)-methylguanine, and other methylated moieties of DNA...

Oligo-1,6-Glucosidase - An enzyme that catalyzes the endohydrolysis of 1,6-alpha-glucosidic linkages in isomaltose and dextr...

omega-Crystallins - A type of crystallin that has been found in the lens (LENS, CRYSTALLINE) of certain species of MOLLU...

Oncogene Protein p21(ras) - Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can ...

Oncogene Protein pp60(v-src) - A tyrosine-specific protein kinase encoded by the v-src oncogene of ROUS SARCOMA VIRUS. The transfor...

Oncogene Protein v-akt - A viral oncoprotein originally isolated from a murine T CELL LYMPHOMA infected with the acutely tran...

Oncogene Proteins v-raf - A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are...

One-Carbon Group Transferases - A subclass of transferases that transfer chemical groups containing a single carbon. These include t...

Ornithine Carbamoyltransferase - A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) fro...

Ornithine Decarboxylase - A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of poly...

Ornithine-Oxo-Acid Transaminase - A pyridoxal phosphate enzyme that catalyzes the formation of glutamate gamma-semialdehyde and an L-a...

Orotate Phosphoribosyltransferase - The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic ac...

Orotidine-5'-Phosphate Decarboxylase - Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield urid...

Oxidoreductases - The class of all enzymes catalyzing oxidoreduction reactions. The substrate that is oxidized is rega...

Oxidoreductases Acting on Aldehyde or Oxo Group Donors - A broad category of oxidoreductases that either reduce double bonds or oxidize single bonds between ...

Oxidoreductases Acting on CH-CH Group Donors - A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. This enzyme g...

Oxidoreductases Acting on CH-NH Group Donors - Enzymes catalyzing the dehydrogenation of secondary amines, introducing a C=N double bond as the pri...

Oxidoreductases Acting on CH-NH2 Group Donors - Enzymes catalyzing the dehydrogenation of or oxidation of compounds containing primary amines....

Oxidoreductases Acting on Sulfur Group Donors - Oxidoreductases with specificity for oxidation or reduction of SULFUR COMPOUNDS....

Oxidoreductases, O-Demethylating - Drug metabolizing enzymes which oxidize methyl ethers. Usually found in liver microsomes....

Oxo-Acid-Lyases - Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) E...

Oxygenases - Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecul...

p21-Activated Kinases - A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEIN...

p300-CBP Transcription Factors - A family of histone acetyltransferases that is structurally-related to CREB-BINDING PROTEIN and to E...

p38 Mitogen-Activated Protein Kinases - A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes includin...

Palmitoyl-CoA Hydrolase - Enzyme catalyzing reversibly the hydrolysis of palmitoyl-CoA or other long-chain acyl coenzyme A com...

Pancreatic alpha-Amylases - A subclass of alpha-amylase ISOENZYMES that are secreted into PANCREATIC JUICE....

Pancreatic Elastase - A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,...

Pancreatin - A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It ...

Pancrelipase - A preparation of hog pancreatic enzymes standardized for lipase content....

Papain - A proteolytic enzyme obtained from Carica papaya. It is also the name used for a purified mixture of...

Penicillin Amidase - An enzyme catalyzing the hydrolysis of penicillin to penicin and a carboxylic acid anion. EC 3.5.1.1...

Penicillinase - A beta-lactamase preferentially cleaving penicillins. (Dorland, 28th ed) EC 3.5.2.-....

Penicillin-Binding Proteins - Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACT...

Pentosyltransferases - Enzymes of the transferase class that catalyze the transfer of a pentose group from one compound to ...

Pepsin A - Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain...

Peptide Elongation Factor 1 - Peptide elongation factor 1 is a multisubunit protein that is responsible for the GTP-dependent bind...

Peptide Elongation Factor 2 - Peptide Elongation Factor 2 catalyzes the translocation of peptidyl-tRNA from the A site to the P si...

Peptide Elongation Factor G - Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA from the A to the P site of...

Peptide Elongation Factor Tu - A protein found in bacteria and eukaryotic mitochondria which delivers aminoacyl-tRNA's to the A sit...

Peptide Hydrolases - Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of su...

Peptide Synthases - Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds ...

Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. I...

Peptidoglycan Glycosyltransferase - A hexosyltransferase involved in the transfer of disaccharide molecules to the peptidoglycan structu...

Peptidyl Transferases - Acyltransferases that use AMINO ACYL TRNA as the amino acid donor in formation of a peptide bond. Th...

Peptidyl-Dipeptidase A - A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when ne...

Peptidylprolyl Isomerase - An enzyme that catalyzes the isomerization of proline residues within proteins. EC 5.2.1.8....

Peroxidase - A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with...

Peroxiredoxin VI - A peroxiredoxin that is a cytosolic bifunctional enzyme. It functions as a peroxiredoxin via a singl...

Peroxiredoxins - A family of ubiquitously-expressed peroxidases that play a role in the reduction of a broad spectrum...

Pertussis Toxin - One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed o...

Phenylalanine Ammonia-Lyase - An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia....

Phenylalanine Hydroxylase - An enzyme of the oxidoreductase class that catalyzes the formation of L-TYROSINE, dihydrobiopterin, ...

Phenylalanine-tRNA Ligase - An enzyme that activates phenylalanine with its specific transfer RNA. EC 6.1.1.20....

Phenylethanolamine N-Methyltransferase - A methyltransferase that catalyzes the reaction of S-adenosyl-L-methionine and phenylethanolamine to...

PHEX Phosphate Regulating Neutral Endopeptidase - A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a var...

Phosphate Acetyltransferase - An enzyme that catalyzes the synthesis of acetylphosphate from acetyl-CoA and inorganic phosphate. A...

Phosphatidate Phosphatase - A phosphomonoesterase involved in the synthesis of triacylglycerols. It catalyzes the hydrolysis of ...

Phosphatidylcholine-Sterol O-Acyltransferase - An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esteri...

Phosphatidylethanolamine N-Methyltransferase - An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethano...

Phosphatidylinositol Diacylglycerol-Lyase - A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosph...

Phosphatidyl-N-Methylethanolamine N-Methyltransferase - An enzyme that catalyzes the METHYLATION of phosphatidyl-N-methylethanolamine to produce phosphatidy...

Phosphodiesterase I - A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy...

Phosphoenolpyruvate Carboxykinase (ATP) - An enzyme of the lyase class that catalyzes the conversion of ATP and oxaloacetate to ADP, phosphoen...

Phosphoenolpyruvate Carboxykinase (GTP) - An enzyme of the lyase class that catalyzes the conversion of GTP and oxaloacetate to GDP, phosphoen...

Phosphoenolpyruvate Carboxylase - An enzyme with high affinity for carbon dioxide. It catalyzes irreversibly the formation of oxaloace...

Phosphoenolpyruvate Sugar Phosphotransferase System - The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl gr...

Phosphofructokinase-1 - An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ...

Phosphofructokinase-1, Liver Type - An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ...

Phosphofructokinase-1, Muscle Type - An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ...

Phosphofructokinase-1, Type C - An allosteric enzyme that regulates glycolysis by catalyzing the transfer of a phosphate group from ...

Phosphofructokinase-2 - An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a p...

Phosphofructokinases - Allosteric enzymes that regulate glycolysis and gluconeogenesis. These enzymes catalyze phosphoryla...

Phosphoglucomutase - An enzyme that catalyzes the conversion of alpha D-glucose 1-phosphate to alpha D-glucose 6-phosphat...

Phosphogluconate Dehydrogenase - An enzyme of the oxidoreductase class that catalyzes the reaction 6-phospho-D-gluconate and NADP+ to...

Phosphoglycerate Dehydrogenase - An enzyme that catalyzes the oxidation of 3-phosphoglycerate to 3-phosphohydroxypyruvate. It takes p...

Phosphoglycerate Kinase - An enzyme catalyzing the transfer of a phosphate group from 3-phospho-D-glycerate in the presence of...

Phosphoglycerate Mutase - An enzyme that catalyzes the conversion of 2-phospho-D-glycerate to 3-phospho-D-glycerate. EC 5.4.2....

Phosphoinositide Phospholipase C - A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TR...

Phospholipase C beta - A phosphoinositide phospholipase C subtype that is primarily regulated by its association with HETER...

Phospholipase C delta - A phosphoinositide phospholipase C subtype that is structurally defined by the presence of an N-term...

Phospholipase C gamma - A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. ...

Phospholipase D - An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a ...

Phospholipases - A class of enzymes that catalyze the hydrolysis of phosphoglycerides or glycerophosphatidates. EC 3....

Phospholipases A - Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates....

Phospholipases A1 - A phospholipase that hydrolyzes the acyl group attached to the 1-position of PHOSPHOGLYCERIDES....

Phospholipases A2 - Phospholipases that hydrolyzes the acyl group attached to the 2-position of PHOSPHOGLYCERIDES....

Phospholipases A2, Calcium-Independent - A subcategory of structurally-related phospholipases A2 that do not require calcium for activity....

Phospholipases A2, Cytosolic - A subcategory of phospholipases A2 that occur in the CYTOSOL....

Phospholipases A2, Secretory - A subcategory of phospholipases A2 that are secreted from cells. They are 14 kDa proteins containing...

Phosphoprotein Phosphatases - A group of enzymes removing the SERINE- or THREONINE-bound phosphate groups from a wide range of pho...

Phosphopyruvate Hydratase - A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Seve...

Phosphoribosylaminoimidazolecarboxamide Formyltransferase - An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-a...

Phosphoribosylglycinamide Formyltransferase - An enzyme that catalyzes the transfer of a formyl group from N10-formyltetrahydrofolate to N1-(5-pho...

Phosphoric Diester Hydrolases - A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester co...

Phosphoric Monoester Hydrolases - A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of ...

Phosphoric Triester Hydrolases - A class of enzymes that catalyze the hydrolysis of one of the three ester bonds in a phosphotriester...

Phosphorus-Oxygen Lyases - Enzymes that catalyze the cleavage of a phosphorus-oxygen bond by means other than hydrolysis or oxi...

Phosphorylase a - The active form of GLYCOGEN PHOSPHORYLASE that is derived from the phosphorylation of PHOSPHORYLASE ...

Phosphorylase b - The inactive form of GLYCOGEN PHOSPHORYLASE that is converted to the active form PHOSPHORYLASE A via...

Phosphorylase Kinase - An enzyme that catalyzes the conversion of ATP and PHOSPHORYLASE B to ADP and PHOSPHORYLASE A....

Phosphorylase Phosphatase - An enzyme that deactivates glycogen phosphorylase a by releasing inorganic phosphate and phosphoryla...

Phosphorylases - A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as g...

Phosphotransferases - A rather large group of enzymes comprising not only those transferring phosphate but also diphosphat...

Phosphotransferases (Alcohol Group Acceptor) - A group of enzymes that transfers a phosphate group onto an alcohol group acceptor. EC 2.7.1....

Phosphotransferases (Carboxyl Group Acceptor) - A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2...

Phosphotransferases (Nitrogenous Group Acceptor) - A group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group accepto...

Phosphotransferases (Paired Acceptors) - A group of enzymes that transfers two phosphate groups from a donor such as ATP to two different acc...

Phosphotransferases (Phosphate Group Acceptor) - A group of enzymes that catalyzes the transfer of a phosphate group onto a phosphate group acceptor....

Phosphotransferases (Phosphomutases) - A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown ...

Photosynthetic Reaction Center Complex Proteins - Protein complexes that take part in the process of PHOTOSYNTHESIS. They are found in the THYLAKOID M...

Photosystem I Protein Complex - A large multisubunit protein complex that is found in the THYLAKOID MEMBRANE. It uses light energy d...

Photosystem II Protein Complex - A large multisubunit protein complex found in the THYLAKOID MEMBRANE. It uses light energy derived f...

Phytochrome A - The primary plant photoreceptor responsible for perceiving and mediating responses to far-red light....

Plasma Kallikrein - A peptidohydrolytic enzyme that is formed from PREKALLIKREIN by FACTOR XIIA. It activates FACTOR XII...

Plasma Membrane Calcium-Transporting ATPases - Calcium-transporting ATPases found on the PLASMA MEMBRANE that catalyze the active transport of CALC...

Plasminogen Activators - A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are conc...

Plastoquinol-Plastocyanin Reductase - A component of the CYTOCHROME B6F COMPLEX, this enzyme catalyzes the oxidation of plastoquinol-1 to ...

Poly(ADP-ribose) Polymerases - Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleot...

Polygalacturonase - A cell wall-degrading enzyme found in microorganisms and higher plants. It catalyzes the random hydr...

Polyketide Synthases - Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES whic...

Polynucleotide 5'-Hydroxyl-Kinase - An enzyme that catalyzes the transfer of a phosphate group to the 5'-terminal hydroxyl groups of DNA...

Polynucleotide Adenylyltransferase - An enzyme that catalyzes the synthesis of polyadenylic acid from ATP. May be due to the action of RN...

Polynucleotide Ligases - Catalyze the joining of preformed ribonucleotides or deoxyribonucleotides in phosphodiester linkage ...

Polyribonucleotide Nucleotidyltransferase - An enzyme of the transferase class that catalyzes the reaction RNA(n+1) and orthophosphate to yield ...

Polysaccharide-Lyases - A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in poly...

Porphobilinogen Synthase - An enzyme that catalyzes the formation of porphobilinogen from two molecules of 5-aminolevulinic aci...

Positive Transcriptional Elongation Factor B - A transcriptional elongation factor complex that is comprised of a heterodimer of CYCLIN-DEPENDENT K...

Pregnancy-Associated Plasma Protein-A - A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It ...

Prekallikrein - A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has...

Prephenate Dehydratase - An enzyme that catalyzes the conversion of prephenate to phenylpyruvate with the elimination of wate...

Prephenate Dehydrogenase - An enzyme that catalyzes the conversion of prephenate to p-hydroxyphenylpyruvate in the presence of ...

Procollagen N-Endopeptidase - An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical r...

Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase - A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocolla...

Procollagen-Proline Dioxygenase - A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl-containing-peptide, u...

Progesterone Reductase - An enzyme that catalyzes the reduction of a 3 beta-hydroxy-delta(5)-steroid to 3-oxo-delta(4)-steroi...

Proline Oxidase - The first enzyme of the proline degradative pathway. It catalyzes the oxidation of proline to pyrrol...

Proline-Directed Protein Kinases - A subclass of protein serine-threonine kinases that phosphorylate proteins on a SERINE or THREONINE ...

Pronase - A proteolytic enzyme obtained from Streptomyces griseus....

Propanediol Dehydratase - An enzyme that catalyzes the dehydration of 1,2-propanediol to propionaldehyde. EC 4.2.1.28....

Proprotein Convertase 1 - A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired ...

Proprotein Convertase 2 - A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohor...

Proprotein Convertase 5 - A serine endopeptidase found primarily in the EXTRACELLULAR MATRIX. It has specificity for cleavage ...

Proprotein Convertases - Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohor...

Prostaglandin-Endoperoxide Synthases - Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATT...

Prostate-Specific Antigen - A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial c...

Protamine Kinase - An aspect of protein kinase (EC 2.7.1.37) in which serine residues in protamines and histones are ph...

Protease La - A prokaryotic ATP-dependent protease that plays a role in the degradation of many abnormal proteins....

Proteasome Endopeptidase Complex - A large multisubunit complex that plays an important role in the degradation of most of the cytosoli...

Protein D-Aspartate-L-Isoaspartate Methyltransferase - A PROTEIN O-METHYLTRANSFERASE that recognizes and catalyzes the methyl esterification of ISOASPARTI...

Protein Disulfide Reductase (Glutathione) - An enzyme that catalyzes the reduction of a protein-disulfide in the presence of glutathione, formin...

Protein Disulfide-Isomerases - Sulfur-sulfur bond isomerases that catalyze the rearrangement of disulfide bonds within proteins dur...

Protein Kinase C - An serine-threonine protein kinase that requires the presence of physiological concentrations of CAL...

Protein Kinase C-alpha - A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLI...

Protein Kinase C-delta - A ubiquitously expressed protein kinase that is involved in a variety of cellular SIGNAL PATHWAYS. I...

Protein Kinase C-epsilon - A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threon...

Protein Kinases - A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein....

Protein Methyltransferases - Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide ch...

Protein O-Methyltransferase - An enzyme that catalyzes the transfer of methyl groups from S-adenosylmethionine to free carboxyl gr...

Protein Phosphatase 1 - A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of ce...

Protein Phosphatase 2 - A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regu...

Protein Tyrosine Phosphatase, Non-Receptor Type 1 - A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting moti...

Protein Tyrosine Phosphatase, Non-Receptor Type 11 - A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutat...

Protein Tyrosine Phosphatase, Non-Receptor Type 12 - A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N...

Protein Tyrosine Phosphatase, Non-Receptor Type 13 - A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an ...

Protein Tyrosine Phosphatase, Non-Receptor Type 2 - A subtype of non-receptor protein tyrosine phosphatase that is closely-related to PROTEIN TYROSINE P...

Protein Tyrosine Phosphatase, Non-Receptor Type 22 - A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an ...

Protein Tyrosine Phosphatase, Non-Receptor Type 3 - A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an ...

Protein Tyrosine Phosphatase, Non-Receptor Type 4 - A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an ...

Protein Tyrosine Phosphatase, Non-Receptor Type 6 - A Src-homology domain-containing protein tyrosine phosphatase found in the CYTOSOL of hematopoietic ...

Protein Tyrosine Phosphatases - An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Tog...

Protein Tyrosine Phosphatases, Non-Receptor - A subcategory of protein tyrosine phosphatases that occur in the CYTOPLASM. Many of the proteins in ...

Protein-Arginine N-Methyltransferases - Enzymes that catalyze the methylation of arginine residues of proteins to yield N-mono- and N,N-dime...

Protein-Lysine 6-Oxidase - An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield pept...

Protein-Serine-Threonine Kinases - A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, w...

Protein-Tyrosine Kinases - Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other...

Protocatechuate-3,4-Dioxygenase - An enzyme that catalyzes the oxidation of protocatechuate to 3-carboxy-cis-cis-muconate in the prese...

Proton-Translocating ATPases - Multisubunit enzymes that reversibly synthesize ADENOSINE TRIPHOSPHATE. They are coupled to the tran...

Proto-Oncogene Proteins B-raf - A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kina...

Proto-Oncogene Proteins c-abl - Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm...

Proto-Oncogene Proteins c-akt - A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS...

Proto-Oncogene Proteins c-bcr - Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of CE...

Proto-Oncogene Proteins c-cbl - Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a...

Proto-Oncogene Proteins c-fes - Proto-oncogene proteins fes are protein-tyrosine kinases with a central SH2 DOMAIN. It has been impl...

Proto-Oncogene Proteins c-fyn - Src-family kinases that associate with T-CELL ANTIGEN RECEPTOR and phosphorylate a wide variety of i...

Proto-Oncogene Proteins c-hck - Members of the src-family tyrosine kinase family that are strongly expressed in MYELOID CELLS and B-...

Proto-Oncogene Proteins c-kit - A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucia...

Proto-Oncogene Proteins c-mdm2 - An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to...

Proto-Oncogene Proteins c-met - Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extr...

Proto-Oncogene Proteins c-mos - Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to mainta...

Proto-Oncogene Proteins c-pim-1 - Serine-threonine protein kinases that relay signals from CYTOKINE RECEPTORS and are involved in cont...

Proto-Oncogene Proteins c-raf - A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. T...

Proto-Oncogene Proteins c-ret - Receptor protein-tyrosine kinases involved in the signaling of GLIAL CELL-LINE DERIVED NEUROTROPHIC ...

Proto-Oncogene Proteins c-yes - Members of the src-family tyrosine kinases that are activated during the transition from G2 PHASE to...

Proto-Oncogene Proteins p21(ras) - Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and...

Proto-Oncogene Proteins pp60(c-src) - Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important rol...

Protoporphyrinogen Oxidase - A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen...

Pseudocholinesterase - An aspect of cholinesterases....

PTEN Phosphohydrolase - A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL...

Purine-Nucleoside Phosphorylase - An enzyme that catalyzes the reaction between a purine nucleoside and orthophosphate to form a free ...

Pyridoxal Kinase - An enzyme that catalyzes reversibly the phosphorylation of pyridoxal in the presence of ATP with the...

Pyridoxaminephosphate Oxidase - An enzyme catalyzing the deamination of pyridoxaminephosphate to pyridoxal phosphate. It is a flavop...

Pyroglutamate Hydrolase - Hydrolyzes pyroglutamic acid in the presence of ATP to glutamate plus ADP and inorganic phosphate. D...

Pyroglutamyl-Peptidase I - An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided ...

Pyrophosphatases - A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, ch...

Pyrroline Carboxylate Reductases - A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence...

Pyruvate Carboxylase - A biotin-dependent enzyme belonging to the ligase family that catalyzes the addition of CARBON DIOXI...

Pyruvate Decarboxylase - Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyro...

Pyruvate Dehydrogenase (Lipoamide) - The E1 component of the multienzyme PYRUVATE DEHYDROGENASE COMPLEX. It is composed of 2 alpha subuni...

Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - (Pyruvate dehydrogenase (lipoamide))-phosphate phosphohydrolase. A mitochondrial enzyme that catalyz...

Pyruvate Dehydrogenase Complex - A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme c...

Pyruvate Kinase - ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylat...

Pyruvate Synthase - A ferredoxin-containing enzyme that catalyzes the COENZYME A-dependent oxidative decarboxylation of ...

Pyruvate, Orthophosphate Dikinase - An enzyme that catalyzes the reaction of ATP, pyruvate, and orthophosphate to form AMP plus phosphoe...

Q beta Replicase - An enzyme that catalyzes the replication of the RNA of coliphage Q beta. EC 2.7.7.-....

Quinone Reductases - NAD(P)H:(quinone acceptor) oxidoreductases. A family that includes three enzymes which are distingui...

rab GTP-Binding Proteins - A large family of MONOMERIC GTP-BINDING PROTEINS that play a key role in cellular secretory and endo...

rab1 GTP-Binding Proteins - A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in vesicle transport between th...

rab2 GTP-Binding Protein - A protein involved in transport between the ENDOPLASMIC RETICULUM and the GOLGI APPARATUS. This enzy...

rab3 GTP-Binding Proteins - A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in calcium-dependent EXOCYTOSIS...

rab3A GTP-Binding Protein - The most abundant member of the RAB3 GTP-BINDING PROTEINS. It is involved in calcium-dependent EXOCY...

rab4 GTP-Binding Proteins - A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in recycling of proteins such a...

rab5 GTP-Binding Proteins - A genetically related subfamily of RAB GTP-BINDING PROTEINS involved in transport from the cell memb...

rac GTP-Binding Proteins - A sub-family of RHO GTP-BINDING PROTEINS that is involved in regulating the organization of cytoskel...

rac1 GTP-Binding Protein - A rac GTP-binding protein involved in regulating actin filaments at the plasma membrane. It controls...

Racemases and Epimerases - Enzymes that catalyze inversion of the configuration around an asymmetric carbon in a substrate havi...

Rad51 Recombinase - A Rec A recombinase found in eukaryotes. Rad51 is involved in DNA REPAIR of double-strand breaks....

raf Kinases - A family of closely-related serine-threonine kinases that were originally identified as the cellular...

ral GTP-Binding Proteins - A family of ubiquitously expressed MONOMERIC GTP-BINDING PROTEINS that are involved in intracellular...

ran GTP-Binding Protein - A monomeric GTP-binding protein involved in nucleocytoplasmic transport of proteins into the nucleus...

rap GTP-Binding Proteins - A family of MONOMERIC GTP-BINDING PROTEINS that are related to RAS PROTEINS.This enzyme was formerly...

rap1 GTP-Binding Proteins - A genetically related subfamily of RAP GTP-BINDING PROTEINS that share homology with RAS PROTEINS. T...

ras Proteins - Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived p...

Rec A Recombinases - A family of recombinases initially identified in BACTERIA. They catalyze the ATP-driven exchange of ...

Receptor Protein-Tyrosine Kinases - A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity....

Receptor Tyrosine Kinase-like Orphan Receptors - A family of cell surface receptors that were originally identified by their structural homology to n...

Receptor, EphA1 - The founding member of the EPH FAMILY RECEPTORS. It was first cloned from an erythropoietin-producin...

Receptor, EphA2 - An Eph family receptor found abundantly in tissues of epithelial origin. It is expressed in a divers...

Receptor, EphA3 - An eph family receptor that is found primarily in adult BRAIN and variety of tissues in the developi...

Receptor, EphA4 - An eph family receptor found in variety of tissues including BRAIN. During embryogenesis, EphA4 rece...

Receptor, EphA5 - An eph family receptor found primarily in differentiated neuronal tissues. Several isoforms of EphA5...

Receptor, EphA6 - An eph family receptor that is found in a variety of neuronal regions of the BRAIN. In contrast to t...

Receptor, EphA7 - An eph family receptor found widely expressed in embryo tissues, including the NERVOUS SYSTEM. In th...

Receptor, EphA8 - An eph family receptor found exclusively in BRAIN. EphA8 receptors may play a role in the axonal gui...

Receptor, EphB1 - An eph family receptor found primarily in the nervous system. In the embryonic BRAIN EphB1 receptor ...

Receptor, EphB2 - An eph family receptor found widely expressed in embryonic and adult tissues. High levels of EphB2 r...

Receptor, EphB3 - An eph family receptor found in a number of tissues including BRAIN; LUNG; KIDNEY; PANCREAS; INTESTI...

Receptor, EphB4 - An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of pro...

Receptor, EphB5 - An eph family receptor found at high levels in adult THYMUS and RETINA. In embryonic tissues it is f...

Receptor, Epidermal Growth Factor - A cell surface receptor involved in regulation of cell growth and differentiation. It is specific fo...

Receptor, erbB-2 - A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant n...

Receptor, erbB-3 - A cell surface protein-tyrosine kinase receptor that is specific for NEUREGULINS. It has extensive h...

Receptor, Fibroblast Growth Factor, Type 1 - A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE ...

Receptor, Fibroblast Growth Factor, Type 2 - A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in ...

Receptor, Fibroblast Growth Factor, Type 3 - A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Muta...

Receptor, Fibroblast Growth Factor, Type 4 - A fibroblast growth factor receptor that is mainly expressed in LUNG; KIDNEY; PANCREAS; and SPLEEN. ...

Receptor, IGF Type 1 - A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Alt...

Receptor, Insulin - A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits whic...

Receptor, Macrophage Colony-Stimulating Factor - A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS)...

Receptor, Platelet-Derived Growth Factor alpha - A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a prote...

Receptor, Platelet-Derived Growth Factor beta - A PDGF receptor that binds specifically to the PDGF-B chain. It contains a protein-tyrosine kinase a...

Receptor, TIE-1 - A TIE receptor found predominantly on ENDOTHELIAL CELLS. It is considered essential for vascular dev...

Receptor, TIE-2 - A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required...

Receptor, trkA - A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotr...

Receptor, trkB - A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROP...

Receptor, trkC - A protein-tyrosine kinase receptor that is specific for NEUROTROPHIN 3. It is widely expressed in ne...

Receptor-Interacting Protein Serine-Threonine Kinase 2 - A RIP serine-theonine kinase that contains a C-terminal caspase activation and recruitment domain. I...

Receptor-Interacting Protein Serine-Threonine Kinases - A family of serine-threonine kinases that plays a role in intracellular signal transduction by inter...

Receptor-Like Protein Tyrosine Phosphatases - A subcategory of protein tyrosine phosphatases that are bound to the cell membrane. They contain cyt...

Receptor-Like Protein Tyrosine Phosphatases, Class 1 - A subclass of receptor-like protein tryosine phosphatases that contain heavily glycosylated and cyst...

Receptor-Like Protein Tyrosine Phosphatases, Class 2 - A subclass of receptor-like protein tryosine phosphatases that contain multiple extracellular immuno...

Receptor-Like Protein Tyrosine Phosphatases, Class 3 - A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein ty...

Receptor-Like Protein Tyrosine Phosphatases, Class 4 - A subclass of receptor-like protein tryosine phosphatases that contain short highly glycosylated ext...

Receptor-Like Protein Tyrosine Phosphatases, Class 5 - A subclass of receptor-like protein tryosine phosphatases that contain an extracellular fibronectin ...

Receptor-Like Protein Tyrosine Phosphatases, Class 7 - A subclass of receptor-like protein tryosine phosphatases that contain a short extracellular domain,...

Receptor-Like Protein Tyrosine Phosphatases, Class 8 - A subclass of receptor-like protein tryosine phosphatases that contain an extracellular RDGS-adhesio...

Receptors, Atrial Natriuretic Factor - Cell surface proteins that bind ATRIAL NATRIURETIC FACTOR with high affinity and trigger intracellul...

Receptors, Eph Family - A large family of receptor protein-tyrosine kinases that are structurally-related. The name of this ...

Receptors, Guanylate Cyclase-Coupled - A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or a...

Receptors, Platelet-Derived Growth Factor - Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or...

Receptors, TIE - A family of structurally-related tyrosine kinase receptors that are expressed predominantly in ENDOT...

Receptors, Vascular Endothelial Growth Factor - A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth ...

Recombinases - A broad category of enzymes that are involved in the process of GENETIC RECOMBINATION....

RecQ Helicases - A family of structurally-related DNA helicases that play an essential role in the maintenance of gen...

Renin - A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSI...

Retinal Dehydrogenase - A metalloflavoprotein enzyme involved the metabolism of VITAMIN A, this enzyme catalyzes the oxidati...

Retinoblastoma-Binding Protein 2 - A retinoblastoma binding protein that is also a member of the Jumonji-domain histone demethylases. I...

Retinoblastoma-Binding Protein 4 - A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, an...

Retinoblastoma-Binding Protein 7 - A retinoblastoma-binding protein that is found as a subunit of protein complexes involved in the ace...

Retinol O-Fatty-Acyltransferase - An enzyme that catalyzes the acyl group transfer of acyl COENZYME A to RETINOL to generate COENZYME ...

rho GTP-Binding Proteins - A large family of MONOMERIC GTP-BINDING PROTEINS that are involved in regulation of actin organizati...

rhoA GTP-Binding Protein - A RHO GTP-BINDING PROTEIN involved in regulating signal transduction pathways that control assembly ...

rho-Associated Kinases - A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. T...

rhoB GTP-Binding Protein - A GTP-BINDING PROTEIN involved in regulating a signal transduction pathway that controls assembly of...

Riboflavin Synthase - An enzyme that catalyzes the formation of riboflavin from two molecules of 6,7-dimethyl-8-ribityllum...

Ribonuclease H - A ribonuclease that specifically cleaves the RNA moiety of RNA:DNA hybrids. It has been isolated fro...

Ribonuclease H, Human Immunodeficiency Virus - A ribonuclease activity that is a component of the HIV REVERSE TRANSCRIPTASE. It removes the RNA str...

Ribonuclease III - An endoribonuclease that is specific for double-stranded RNA. It plays a role in POST-TRANSCRIPTIONA...

Ribonuclease P - An RNA-containing enzyme that plays an essential role in tRNA processing by catalyzing the endonucle...

Ribonuclease T1 - An enzyme catalyzing the endonucleolytic cleavage of RNA at the 3'-position of a guanylate residue. ...

Ribonuclease, Pancreatic - An enzyme that catalyzes the endonucleolytic cleavage of pancreatic ribonucleic acids to 3'-phosphom...

Ribonucleases - Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-....

Ribonucleoside Diphosphate Reductase - An enzyme of the oxidoreductase class that catalyzes the formation of 2'-deoxyribonucleotides from t...

Ribose-Phosphate Pyrophosphokinase - An enzyme that catalyzes the formation of phosphoribosyl pyrophosphate from ATP and ribose-5-phospha...

Ribosomal Protein S6 Kinases - A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ri...

Ribosomal Protein S6 Kinases, 70-kDa - A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIB...

Ribosomal Protein S6 Kinases, 90-kDa - A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN ...

Ribosome Inactivating Proteins - N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop...

Ribosome Inactivating Proteins, Type 1 - Ribosome inactivating proteins consisting of only the toxic A subunit, which is a polypeptide of aro...

Ribosome Inactivating Proteins, Type 2 - Ribosome inactivating proteins consisting of two polypeptide chains, the toxic A subunit and a lecti...

Ribulose-Bisphosphate Carboxylase - A copper protein that catalyzes the formation of 2 moles of 3-phosphoglycerate from ribulose 1,5-bip...

Ricin - A protein phytotoxin from the seeds of Ricinus communis, the castor oil plant. It agglutinates cells...

RNA Helicases - A family of proteins that promote unwinding of RNA during splicing and translation. EC 2.7.7.-....

RNA Ligase (ATP) - An enzyme that catalyzes the conversion of linear RNA to a circular form by the transfer of the 5'-p...

RNA Nucleotidyltransferases - Enzymes that catalyze the template-directed incorporation of ribonucleotides into an RNA chain. EC 2...

RNA Polymerase I - A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. The enzyme functions i...

RNA Polymerase II - A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nu...

RNA Polymerase III - A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nu...

RNA Polymerase Sigma 54 - A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subuni...

RNA Replicase - An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucl...

RNA, Catalytic - RNA that has catalytic activity. The catalytic RNA sequence folds to form a complex surface that can...

RNA, Ribosomal, Self-Splicing - Components of ribosomal RNA that undergo auto-catalyzed molecular rearrangements of their RNA sequen...

RNA-Directed DNA Polymerase - An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and...

RNA-Induced Silencing Complex - A multicomponent, ribonucleoprotein complex that cleaves specific mRNAs (RNA, MESSENGER) which are t...

Saccharopine Dehydrogenases - Amine oxidoreductases that use either NAD+ (EC 1.5.1.7) or NADP+ (EC 1.5.1.8) as an acceptor to form...

Salivary alpha-Amylases - A subclass of alpha-amylase ISOENZYMES that are secreted into SALIVA....

Sarcoplasmic Reticulum Calcium-Transporting ATPases - Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RET...

Sarcosine Dehydrogenase - A LIVER mitochondrial matrix flavoenzyme that catalyzes the oxidation of SARCOSINE to GLYCINE and FO...

Sarcosine Oxidase - A FLAVOPROTEIN, this enzyme catalyzes the oxidation of SARCOSINE to GLYCINE; FORMALDEHYDE; and HYDRO...

Serine C-Palmitoyltransferase - A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-depende...

Serine Endopeptidases - Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in...

Serine O-Acetyltransferase - An enzyme that catalyzes the conversion of L-SERINE to COENZYME A and O-acetyl-L-serine, using ACETY...

Serine Proteases - Peptide hydrolases that contain at the active site a SERINE residue involved in catalysis....

Serine-tRNA Ligase - An enzyme that activates serine with its specific transfer RNA. EC 6.1.1.11....

Serine-Type D-Ala-D-Ala Carboxypeptidase - A carboxypeptidase that is specific for proteins that contain two ALANINE residues on their C-termin...

SH2 Domain-Containing Protein Tyrosine Phosphatases - A subcategory of protein tyrosine phosphatases that contain SH2 type SRC HOMOLOGY DOMAINS. Many of t...

Shiga Toxin - A toxin produced by SHIGELLA DYSENTERIAE. It is the prototype of class of toxins that inhibit protei...

Shiga Toxin 1 - A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It...

Shiga Toxin 2 - A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. It...

Shiga Toxins - A class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA; (RNA,...

Sialyltransferases - A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl tran...

Sin3 Histone Deacetylase and Corepressor Complex - A multisubunit enzyme complex that regulates GENETIC TRANSCRIPTION by deacetylating the HISTONE resi...

Single-Strand Specific DNA and RNA Endonucleases - Enzymes that catalyze the endonucleolytic cleavage of single-stranded regions of DNA or RNA molecule...

Sirtuin 1 - A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with...

Sirtuin 2 - A sirtuin family member found primarily in the CYTOPLASM. It is a multifunctional enzyme that contai...

Sirtuin 3 - A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contain...

Sirtuins - A homologous family of regulatory enzymes that are structurally related to the protein silent mating...

Site-Specific DNA-Methyltransferase (Adenine-Specific) - An enzyme responsible for producing a species-characteristic methylation pattern on adenine residues...

Site-Specific DNA-Methyltransferase (Cytosine-N(4)-Specific) - A DNA-methyltransferase that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to t...

Skeletal Muscle Myosins - Myosin type II isoforms found in skeletal muscle....

SKP Cullin F-Box Protein Ligases - A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a ...

Smooth Muscle Myosins - Myosin type II isoforms found in smooth muscle....

Sodium-Potassium-Exchanging ATPase - An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wa...

Spermidine Synthase - An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthioprop...

Spermine Synthase - An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthioprop...

Sphingomyelin Phosphodiesterase - An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus cholin...

Sphingosine N-Acyltransferase - An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME...

Squalene Monooxygenase - The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the f...

src-Family Kinases - A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma viru...

Starch Phosphorylase - An enzyme of the PHOSPHORYLASES family that catalyzes the degradation of starch, a mixture of unbran...

Starch Synthase - An enzyme that catalyzes the transfer of glucose from ADPglucose to glucose-containing polysaccharid...

Stearoyl-CoA Desaturase - An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxyge...

Steroid 11-beta-Hydroxylase - A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the p...

Steroid 12-alpha-Hydroxylase - A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spect...

Steroid 16-alpha-Hydroxylase - A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spect...

Steroid 17-alpha-Hydroxylase - A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pre...

Steroid 21-Hydroxylase - An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the ...

Steroid Hydroxylases - Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthes...

Steroid Isomerases - Enzymes that catalyze the transposition of double bond(s) in a steroid molecule. EC 5.3.3....

Sterol Esterase - An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liber...

Sterol O-Acyltransferase - An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty aci...

Steryl-Sulfatase - An arylsulfatase with high specificity towards sulfated steroids. Defects in this enzyme are the cau...

Streptodornase and Streptokinase - A mixture of the enzymes (streptokinase and streptodornase) produced by hemolytic streptococci. It i...

Streptokinase - Streptococcal fibrinolysin . An enzyme produced by hemolytic streptococci. It hydrolyzes amide linka...

Subtilisin - A serine endopeptidase isolated from Bacillus subtilis. It hydrolyzes proteins with broad specificit...

Subtilisins - A family of SERINE ENDOPEPTIDASES isolated from Bacillus subtilis. EC 3.4.21.-...

Succinate Cytochrome c Oxidoreductase - An electron transport chain complex that catalyzes the transfer of electrons from SUCCINATE to CYTOC...

Succinate Dehydrogenase - A flavoprotein containing oxidoreductase that catalyzes the dehdyrogenation of SUCCINATE to fumerate...

Succinate-CoA Ligases - Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible for...

Succinate-Semialdehyde Dehydrogenase - An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxi...

Succinate-Semialdehyde Dehydrogenase (NADP+) - An enzyme that catalyzes the oxidation of succinate semialdehyde to SUCCINIC ACID. It plays a role i...

Succinyldiaminopimelate Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer amino group from N-succinyl-L-2,...

Sucrase-Isomaltase Complex - An enzyme complex found in the brush border membranes of the small intestine. It is believed to be a...

Sugar Alcohol Dehydrogenases - Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldeh...

Sulfate Adenylyltransferase - An enzyme that catalyzes the activation of sulfate ions by ATP to form adenosine-5'-phosphosulfate a...

Sulfite Dehydrogenase - An enzyme that catalyzes oxidation of sulfite to sulfate along with the reduction of FERROCYTOCHROME...

Sulfite Oxidase - A MOLYBDENUM requiring enzyme that catalyzes the terminal reaction in the oxidative degradation of S...

Sulfite Reductase (Ferredoxin) - A FERREDOXIN-dependent oxidoreductase that is primarily found in PLANTS where it plays an important ...

Sulfite Reductase (NADPH) - A NADPH-dependent oxidase that reduces hydrogen sulfite to HYDROGEN SULFIDE. It is found in many mic...

Sulfotransferases - Enzymes which transfer sulfate groups to various acceptor molecules. They are involved in posttransl...

Sulfur Group Transferases - Enzymes that catalyze the transfer of sulfur atoms (2.8.1), sulfur groups (2.8.2) or coenzyme A (2.8...

Sulfur-Sulfur Bond Isomerases - Enzymes that catalyze the transposition of a sulfur-sulfur bond. EC 5.3.4....

Sulfurtransferases - Enzymes which transfer sulfur atoms to various acceptor molecules. EC 2.8.1....

Superoxide Dismutase - An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecu...

Tacrolimus Binding Protein 1A - A 12-KDa tacrolimus binding protein that is found associated with and may modulate the function of c...

Tacrolimus Binding Proteins - A family of immunophilin proteins that bind to the immunosuppressive drugs TACROLIMUS (also known as...

Tankyrases - A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and...

Taq Polymerase - A heat stable DNA-DIRECTED DNA POLYMERASE from the bacteria Thermus aquaticus. It is widely used for...

tau-Crystallins - A type of crystallin that has been found in the lens (LENS, CRYSTALLINE) of certain species of VERTE...

Telomerase - An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryot...

Tetrahydrofolate Dehydrogenase - An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yiel...

Thermolysin - A thermostable extracellular metalloendopeptidase containing four calcium ions. (Enzyme Nomenclature...

Thermosomes - Group II chaperonins found in species of ARCHAEA....

Thiamin Pyrophosphokinase - An enzyme that catalyzes the formation of thiamine pyrophosphate from ATP and thiamine. EC 2.7.6.2....

Thiamine Pyrophosphatase - An enzyme that hydrolyzes thiamine pyrophosphate to thiamine monophosphate plus inorganic phosphate....

Thiamin-Triphosphatase - An enzyme present in nerve tissue. It catalyzes reversibly the formation of thiamine diphosphate and...

Thioredoxin Reductase 1 - A subtype of thioredoxin reductase found primarily in the CYTOSOL....

Thioredoxin Reductase 2 - A subtype of thioredoxin reductase found primarily in MITOCHONDRIA....

Thioredoxin-Disulfide Reductase - A FLAVOPROTEIN enzyme that catalyzes the oxidation of THIOREDOXINS to thioredoxin disulfide in the p...

Thiosulfate Sulfurtransferase - An enzyme that catalyzes the transfer of the planetary sulfur atom of thiosulfate ion to cyanide ion...

Threonine Dehydratase - A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMO...

Threonine-tRNA Ligase - An enzyme that activates threonine with its specific transfer RNA. EC 6.1.1.3....

Thrombin - An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN....

Thromboxane-A Synthase - An enzyme found predominantly in platelet microsomes. It catalyzes the conversion of PGG(2) and PGH(...

Thymidine Kinase - An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deox...

Thymidine Phosphorylase - The enzyme catalyzing the transfer of 2-deoxy-D-ribose from thymidine to orthophosphate, thereby lib...

Thymidylate Synthase - An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dU...

Thymine DNA Glycosylase - An enzyme that removes THYMINE and URACIL bases mispaired with GUANINE through hydrolysis of their N...

Tissue Kallikreins - A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types includi...

Tissue Plasminogen Activator - A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN ...

Tolloid-Like Metalloproteinases - A family of metalloproteases that are related to the DROSOPHILA protein tolloid, which is a gene pro...

Transaldolase - An enzyme of the transferase class that catalyzes the reaction sedoheptulose 7-phosphate and D-glyce...

Transaminases - A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a d...

Trans-Cinnamate 4-Monooxygenase - A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropan...

Transducin - A heterotrimeric GTP-binding protein that mediates the light activation signal from photolyzed rhodo...

Transferases - Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, fr...

Transferases (Other Substituted Phosphate Groups) - A class of enzymes that transfers substituted phosphate groups. EC 2.7.8....

Transglutaminases - Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in anot...

Transketolase - An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-...

Transposases - Enzymes that recombine DNA segments by a process which involves the formation of a synapse between t...

Transposon Resolvases - Recombinases that involved in the propagation of DNA TRANSPOSONS. They bind to transposon sequences ...

Trehalase - An enzyme that catalyzes the conversion of alpha,alpha-trehalose and water to D-glucose. EC 3.2.1.28...

Triose-Phosphate Isomerase - An enzyme that catalyzes reversibly the conversion of D-glyceraldehyde 3-phosphate to dihydroxyaceto...

tRNA Methyltransferases - Enzymes that catalyze the S-adenosyl-L-methionine-dependent methylation of ribonucleotide bases with...

Trypsin - A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its act...

Tryptases - A family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in th...

Tryptophan Hydroxylase - An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of N...

Tryptophan Oxygenase - A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVE...

Tryptophan Synthase - An enzyme that catalyzes the conversion of L-serine and 1-(indol-3-yl)glycerol 3-phosphate to L-tryp...

Tryptophan Transaminase - A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer amino group from L-TRYPTOPHAN to...

Tryptophanase - An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. ...

Tryptophan-tRNA Ligase - An enzyme that activates tryptophan with its specific transfer RNA. EC 6.1.1.2....

TYK2 Kinase - A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The...

Type C Phospholipases - A subclass of phospholipases that hydrolyze the phosphoester bond found in the third position of GLY...

Tyrosine 3-Monooxygenase - An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydr...

Tyrosine Decarboxylase - A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dio...

Tyrosine Phenol-Lyase - An enzyme that catalyzes the cleavage of tyrosine to phenol, pyruvate, and ammonia. It is a pyridoxa...

Tyrosine Transaminase - An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate ...

Tyrosine-tRNA Ligase - An enzyme that activates tyrosine with its specific transfer RNA. EC 6.1.1.1....

Ubiquitin Thiolesterase - A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIO...

Ubiquitin-Activating Enzymes - A class of enzymes that catalyzes the ATP-dependent formation of a thioester bond between itself and...

Ubiquitin-Conjugating Enzymes - A class of enzymes that form a thioester bond to UBIQUITIN with the assistance of UBIQUITIN-ACTIVATI...

Ubiquitin-Protein Ligase Complexes - Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming...

Ubiquitin-Protein Ligases - A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-speci...

UDPglucose 4-Epimerase - A necessary enzyme in the metabolism of galactose. It reversibly catalyzes the conversion of UDPgluc...

UDPglucose-Hexose-1-Phosphate Uridylyltransferase - An enzyme that catalyzes the transfer of UMP from UDPglucose to galactose 1-phosphate, forming UDPga...

Uracil-DNA Glycosidase - An enzyme that catalyzes the HYDROLYSIS of the N-glycosidic bond between sugar phosphate backbone an...

Urate Oxidase - An enzyme that catalyzes the conversion of urate and unidentified products. It is a copper protein. ...

Urease - An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5....

Uridine Diphosphate Glucose Dehydrogenase - An enzyme that catalyzes the oxidation of UDPglucose to UDPglucuronate in the presence of NAD+. EC 1...

Uridine Kinase - An enzyme that catalyzes the phosphorylation of uridine and cytidine to uridine 5'-phosphate and cyt...

Uridine Phosphorylase - An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and r...

Urocanate Hydratase - An enzyme that catalyzes the conversion of 4,5-dihydro-4-oxo-5-imidazolepropanoate to urocanate and ...

Urokinase-Type Plasminogen Activator - A proteolytic enzyme that converts PLASMINOGEN to FIBRINOLYSIN where the preferential cleavage is be...

Uroporphyrinogen Decarboxylase - An enzyme that catalyzes the decarboxylation of UROPORPHYRINOGEN III to coproporphyrinogen III by th...

Uroporphyrinogen III Synthetase - An enzyme that catalyzes the cyclization of hydroxymethylbilane to yield UROPORPHYRINOGEN III and wa...

UTP-Glucose-1-Phosphate Uridylyltransferase - An enzyme that catalyzes the formation of UDPglucose from UTP plus glucose 1-phosphate. EC 2.7.7.9....

UTP-Hexose-1-Phosphate Uridylyltransferase - An enzyme that catalyzes the synthesis of UDPgalactose from UTP and galactose-1-phosphate. It is pre...

Vacuolar Proton-Translocating ATPases - Proton-translocating ATPases that are involved in acidification of a variety of intracellular compar...

Valine Dehydrogenase (NADP+) - An amino acid oxidoreductase that catalyzes the oxidative hydroxylation of L-VALINE to 3-methyl-2-ox...

Valine-tRNA Ligase - An enzyme that activates valine with its specific transfer RNA. EC 6.1.1.9...

Vascular Endothelial Growth Factor Receptor-1 - A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis an...

Vascular Endothelial Growth Factor Receptor-2 - A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in en...

Vascular Endothelial Growth Factor Receptor-3 - A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult...

VDJ Recombinases - Recombinases involved in the rearrangement of immunity-related GENES such as IMMUNOGLOBULIN GENES an...

Venombin A - A thrombin-like enzyme from the venom of snakes of the viper/rattlesnake group. Species variants of ...

Ventricular Myosins - Isoforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in th...

Von Hippel-Lindau Tumor Suppressor Protein - A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FA...

Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate - The lectin wheatgerm agglutinin conjugated to the enzyme HORSERADISH PEROXIDASE. It is widely used f...

Xanthine Dehydrogenase - An enzyme that catalyzes the oxidation of XANTHINE in the presence of NAD+ to form URIC ACID and NAD...

Xanthine Oxidase - An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, s...

Xeroderma Pigmentosum Group D Protein - A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCL...

Xylan Endo-1,3-beta-Xylosidase - A xylosidase that catalyses the random hydrolysis of 1,3-beta-D-xylosidic linkages in 1,3-beta-D-xyl...

Xylosidases - A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 cat...

ZAP-70 Protein-Tyrosine Kinase - A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR functi...

zeta-Crystallins - A group of crystallins that have been found in the lens (LENS, CRYSTALLINE) of certain species of VE...

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Common Chronic Illnesses

Coronary Disease

An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Diabetes Mellitus, Type 1

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
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Diabetes Mellitus, Type 2

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
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Hypertension

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Mesothelioma

A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)

Osteoarthritis

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

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