Steroid Hydroxylases
Categorical breakdown of terms falling inder the category of Steroid Hydroxylases. Sub categories will become more specific in nature to the terms listed for Steroid Hydroxylases.
Sub-Categories
Terms
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin...
Aldosterone Synthase - A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presen...
Aromatase - An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and convert...
Cholesterol 7-alpha-Hydroxylase - A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in t...
Cholesterol Side-Chain Cleavage Enzyme - A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to ...
Cytochrome P-450 CYP27A1 - An NAPH-dependent cytochrome P450 enzyme that catalyzes the oxidation of the side chain of sterol in...
Steroid 11-beta-Hydroxylase - A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the p...
Steroid 12-alpha-Hydroxylase - A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spect...
Steroid 16-alpha-Hydroxylase - A liver microsomal cytochrome P450 enzyme that catalyzes the 16-alpha-hydroxylation of a broad spect...
Steroid 17-alpha-Hydroxylase - A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pre...
Steroid 21-Hydroxylase - An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the ...
Steroid Hydroxylases - Cytochrome P-450 monooxygenases (MIXED FUNCTION OXYGENASES) that are important in steroid biosynthes...
Common Chronic Illnesses
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
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Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
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Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
