Molecular Mechanisms of Pharmacological Action
Categorical breakdown of terms falling inder the category of Molecular Mechanisms of Pharmacological Action. Sub categories will become more specific in nature to the terms listed for Molecular Mechanisms of Pharmacological Action.
Sub-Categories
Terms
Adrenergic Agents - Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included...
Adrenergic Agonists - Drugs that bind to and activate adrenergic receptors....
Adrenergic alpha-Agonists - Drugs that selectively bind to and activate alpha adrenergic receptors....
Adrenergic alpha-Antagonists - Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of en...
Adrenergic Antagonists - Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the action...
Adrenergic beta-Agonists - Drugs that selectively bind to and activate beta-adrenergic receptors....
Adrenergic beta-Antagonists - Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of bet...
Adrenergic Uptake Inhibitors - Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicl...
Adrenergic Uptake Inhibitors - Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicl...
Alkylating Agents - Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and there...
Angiotensin II Type 1 Receptor Blockers - Agents that antagonize ANGIOTENSIN II TYPE 1 RECEPTOR. Included are ANGIOTENSIN II analogs such as S...
Angiotensin-Converting Enzyme Inhibitors - A class of drugs whose main indications are the treatment of hypertension and heart failure. They ex...
Antacids - Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT....
Anticholesteremic Agents - Substances used to lower plasma cholesterol levels....
Antifibrinolytic Agents - Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmi...
Antilipemic Agents - Substances used to treat HYPERLIPIDEMIAS....
Antimetabolites - Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere...
Antimetabolites, Antineoplastic - Antimetabolites that are useful in cancer chemotherapy....
Antimitotic Agents - Agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS....
Antineoplastic Agents, Alkylating - A class of drugs that differs from other alkylating agents used clinically in that they are monofunc...
Antioxidants - Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to w...
Aromatase Inhibitors - Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones....
Calcium Channel Agonists - Agents that increase calcium influx into calcium channels of excitable tissues. This causes vasocons...
Calcium Channel Blockers - A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the...
Carbonic Anhydrase Inhibitors - A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inh...
Chelating Agents - Chemicals that bind to and remove ions from solutions. Many chelating agents function through the fo...
Cholinergic Agents - Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, dr...
Cholinergic Agonists - Drugs that bind to and activate cholinergic receptors....
Cholinergic Antagonists - Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYL...
Cholinesterase Inhibitors - Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and th...
Cholinesterase Inhibitors - Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and th...
Cholinesterase Reactivators - Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. T...
Cholinesterase Reactivators - Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. T...
Cyclooxygenase 2 Inhibitors - A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2....
Cyclooxygenase Inhibitors - Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and ther...
Cysteine Proteinase Inhibitors - Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES....
Dipeptidyl-Peptidase IV Inhibitors - Compounds that supress the degradation of INCRETINS by blocking the action of DIPEPTIDYL-PEPTIDASE I...
Dopamine Agents - Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or o...
Dopamine Agonists - Drugs that bind to and activate dopamine receptors....
Dopamine Antagonists - Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine ...
Dopamine Uptake Inhibitors - Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within termi...
Dopamine Uptake Inhibitors - Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within termi...
Endocannabinoids - Endogenous compounds that bind to CANNABINOID RECEPTORS. They are structurally different from the CA...
Enzyme Activators - Compounds or factors that act on a specific enzyme to increase its activity....
Enzyme Inhibitors - Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-...
Enzyme Reactivators - Compounds which restore enzymatic activity by removing an inhibitory group bound to the reactive sit...
Excitatory Amino Acid Agents - Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Includ...
Excitatory Amino Acid Agonists - Drugs that bind to and activate excitatory amino acid receptors....
Excitatory Amino Acid Antagonists - Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions...
Fatty Acid Synthesis Inhibitors - Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a...
Fibrin Modulating Agents - Agents that affect the function of FIBRIN in BLOOD COAGULATION. They used as COAGULANTS for HEMORRHA...
Fibrinolytic Agents - Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN....
Folic Acid Antagonists - Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts d...
Free Radical Scavengers - Substances that influence the course of a chemical reaction by ready combination with free radicals....
GABA Agents - Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include ago...
GABA Agonists - Drugs that bind to and activate GAMMA-AMINOBUTYRIC ACID receptors (RECEPTORS, GABA)....
GABA Antagonists - Drugs that bind to but do not activate GAMMA-AMINOBUTYRIC ACID receptors, thereby blocking the actio...
GABA Modulators - Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID rece...
Glycine Agents - Substances used for their pharmacological actions on glycinergic systems. Glycinergic agents include...
GTP Phosphohydrolase Activators - Agents and factors that activate GTP phosphohydrolase activity....
Heparin Antagonists - Coagulant substances inhibiting the anticoagulant action of heparin....
Histamine Agents - Drugs used for their actions on histaminergic systems. Included are drugs that act at histamine rece...
Histamine Agonists - Drugs that bind to and activate histamine receptors. Although they have been suggested for a variety...
Histamine Antagonists - Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamin...
Histamine H1 Antagonists - Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the acti...
Histamine H1 Antagonists, Non-Sedating - A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGO...
Histamine H2 Antagonists - Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the acti...
Histamine H3 Antagonists - Drugs that selectively bind to but do not activate HISTAMINE H3 RECEPTORS. They have been used to co...
Histone Deacetylase Inhibitors - Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by i...
HIV Fusion Inhibitors - Inhibitors of the fusion of HIV to host cells, preventing viral entry. This includes compounds that ...
HIV Integrase Inhibitors - Inhibitors of HIV INTEGRASE, an enzyme required for integration of viral DNA into cellular DNA....
HIV Protease Inhibitors - Inhibitors of HIV PROTEASE, an enzyme required for production of proteins needed for viral assembly....
Hydroxymethylglutaryl-CoA Reductase Inhibitors - Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthe...
Hydroxymethylglutaryl-CoA Reductase Inhibitors - Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthe...
Integrase Inhibitors - Compounds which inhibit or antagonize biosynthesis or actions of integrase....
Ionophores - Chemical agents that increase the permeability of biological or artificial lipid membranes to specif...
Iron Chelating Agents - Organic chemicals that form two or more coordination links with an iron ion. Once coordination has o...
Lipotropic Agents - Endogenous factors or drugs that act on fat metabolism by hastening the removal of or decreasing the...
Lipoxygenase Inhibitors - Compounds or agents that combine with lipoxygenase and thereby prevent its substrate-enzyme combinat...
Membrane Transport Modulators - Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS....
Mitogens - Substances that stimulate mitosis and lymphocyte transformation. They include not only substances as...
Mitosis Modulators - Agents that affect MITOSIS of CELLS....
Molecular Mechanisms of Pharmacological Action - Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are us...
Monoamine Oxidase Inhibitors - A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamina...
Muscarinic Agonists - Drugs that bind to and activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC). Muscarinic...
Muscarinic Antagonists - Drugs that bind to but do not activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC), the...
Neurotransmitter Agents - Substances used for their pharmacological actions on any aspect of neurotransmitter systems. Neurotr...
Neurotransmitter Uptake Inhibitors - Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles w...
Nicotinic Agonists - Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic ag...
Nicotinic Antagonists - Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of a...
Nitric Oxide Donors - A diverse group of agents, with unique chemical structures and biochemical requirements, which gener...
Nucleic Acid Synthesis Inhibitors - Compounds that inhibit cell production of DNA or RNA....
Phosphodiesterase Inhibitors - Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases....
Potassium Channel Blockers - A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of pota...
Protease Inhibitors - Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES)....
Protein Kinase Inhibitors - Agents that inhibit PROTEIN KINASES....
Protein Synthesis Inhibitors - Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins....
Proton Pump Inhibitors - Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes...
Reverse Transcriptase Inhibitors - Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on...
Serine Proteinase Inhibitors - Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES....
Serotonin Agents - Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin re...
Serotonin Agonists - Agents that have an affinity for serotonin receptors and are able to mimic the effects of serotonin ...
Serotonin Antagonists - Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotoni...
Serotonin Uptake Inhibitors - Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serot...
Serotonin Uptake Inhibitors - Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serot...
Siderophores - Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestratio...
Sodium Channel Blockers - A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium ...
Sodium Chloride Symporter Inhibitors - Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with...
Sodium Potassium Chloride Symporter Inhibitors - Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascendi...
Trypsin Inhibitors - Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds....
Tubulin Modulators - Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES....
Uncoupling Agents - Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synt...
Common Chronic Illnesses
Coronary Disease
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Diabetes Supplies | Diabetic Groups
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Free Diabetes Supplies
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
